葡聚糖修饰的超顺磁性氧化铁纳米粒子的制备及表征  

Preparation and Characterization of Super Paramagnetism Iron Oxide Nanoparticles Modified by Dextran

作　　者：李璇[1] 张宝林[1] 杨高[1] 王军[1] 谢松伯 盛典 

机构地区：[1]桂林理工大学材料科学与工程学院,广西有色金属及特色材料加工重点实验室省部共建国家重点实验室培育基地,桂林541004

出　　处：《人工晶体学报》2014年第10期2705-2709,2716,共6页Journal of Synthetic Crystals

基　　金：国家自然科学基金(51162003)

摘　　要：以乙酰丙酮铁为铁源,聚乙二醇为溶剂,采用高温热分解法制备了超顺磁性氧化铁纳米粒子,得到聚乙二醇修饰的超顺磁性氧化铁纳米粒子,进一步修饰葡聚糖。苯酚-浓硫酸显色法表明葡聚糖修饰在SPIONs表面,获得葡聚糖修饰的氧化铁纳米粒子。采用透射电镜、纳米粒度和Zeta电位分析仪、超导量子干涉仪和热重对产物进行检测。葡聚糖/聚乙二醇修饰的超顺磁性氧化铁纳米粒子的平均粒径为8.7±1.5 nm;水合动力学粒径33 nm,Zeta电位为13mV。葡聚糖/聚乙二醇修饰的超顺磁性氧化铁纳米粒子为超顺磁性,饱和磁化强度为21 emu/g;热重分析表明约有42wt%的葡聚糖和30wt%的PEG修饰在SPIONs表面,计算得到纯氧化铁纳米粒子的饱和磁化强度为75 emu/g。Superparamagnetic iron oxide nanoparticles（ SPIONs） were synthesized by high-temperature thermal decomposition of the iron（ III） acetylacetonate（ Fe（ acac）3） in poly（ ethylene glycol）（ PEG）.SPIONs coated with PEG（ PEG-SPIONs） were obtained. Then PEG-SPIONs were modified with dextran（ Dex）. The results of phenol-sulfuric acid method proved that PEG-SPIONs were coated with Dex. TEM image showed that Dex /PEG-SPIONs had a uniform size distribution with a diameter of 8. 7 ± 1. 5 nm;the hydrodynamic size was 33 nm and the zeta potential value was 13 mV. The Dex /PEG-SPIONs was superparamagnetic with saturation magnetization of 21 emu /g. The results of TGA analysis indicate that there were about 42wt% Dex and 30wt% PEG coating on SPIONs. The calculated saturation magnetization of the iron oxide cores of PEG-SPIONs and Dex /PEG-SPIONs was 75 emu /g.

关 键 词：超顺磁性 氧化铁 葡聚糖 高温热分解法 

分 类 号：TM277[一般工业技术—材料科学与工程]