血浆TNF-α、IL-15、IL-10在子痫前期中的作用  

The role of TNF- α、IL- 15 、IL- 10 in Preeclampsia

作　　者：徐美春 吕玲 于晓妮 

机构地区：[1]山东省青岛市第九人民医院妇产科,山东青岛266002

出　　处：《吉林医学》2014年第34期7580-7582,共3页Jilin Medical Journal

摘　　要：目的:探讨肿瘤坏死因子-α(TNF-α)、白细胞介素-15(IL-15)、白细胞介素-10(IL-10)在子痫前期中的作用。方法:选取子痫前期组44例作为研究组,血压正常组40例作为对照组,用ELISA法测定孕妇血浆TNF-α,IL-15和IL-10。结果:子痫前期组孕妇血浆TNF-α、IL-15明显高于正常组孕妇,差异有统计学意义(T=2.011,T=2.048,P<0.05)。正常孕妇血浆IL-10高于子痫前期组,差异有统计学意义(T=2.035,P<0.05)。结论:本研究表明子痫前期组比血压正常组孕妇血浆TNF-α、IL-15升高,血压正常孕妇血浆IL-10高于子痫前期组。早期检测炎性因子标志物更精确的预测和观察子痫前期。抗炎性因子IL-10水平的升高对子痫前期有保护性作用。Objective To explore the effects of tumor necrosis factor alpha （TNF -α） ,interlcukin - 15 （IL - 15） ,interlcukin - 10 （ IL - 10） in precclampsia. Method We selected the preeclampsia group 44 people as the research group,and normal blood pressure group 40 as control group. We used the Elise method to examine the levels of TNF-α,IL- 15 ,IL - 10 of pregnant women. Results The women with PE showed significantly higher serum levels of TNF -α and IL - 15 （ T = 2. 01 I, T = 2. 048 ,P 〈 0. 05 ） in comparison with blood pressure pregnant women. Conversely,the serum levels of IL - 10 in blood pressure pregnant women were significantly higher compared to PE patients （ T = 2. 035 ,P 〈 0. 05）. Conclusion The results of this study demonstrates that TNF -α,L - 15 are increased in PE women compared to blood pressure pregnant women, serum levels of IL - 10 are increased in blood pressure pregnant women compared to PE. Early detection of inflammatory markers can help us more accurate prediction and observation of preeelampsia. Anti inflammatory eytokine IL - 10 levels increased preeclampsia have a protective effect.

关 键 词：白细胞介素-10 白细胞介素-15 肿瘤坏死因子-α 子痫前期 

分 类 号：R714.244[医药卫生—妇产科学]