血清学筛查在高龄孕妇产前诊断中应用价值分析  

Analyzing the Application of Prenatal Screening in Advanced Maternal Age

作　　者：林元[1] 郑翠仙[1] 曾凡湘[1] 何德钦[1] 徐两蒲[1] 陈水仙[1] 陈小梅[1] 

机构地区：[1]福建医科大学教学医院,福建省妇幼保健院妇产科,福州350001

出　　处：《福建医科大学学报》2014年第4期258-261,共4页Journal of Fujian Medical University

基　　金：福建省科技重大专项(2013YZ0002-1);福建省临床重点专科建设项目(闽卫科教2012149);福建省科技计划重点项目(2012Y0011)

摘　　要：目的：探讨血清学筛查在高龄孕妇产前诊断中的应用价值。方法回顾性分析2012年1月1日-2012年10月31日行胎儿染色体核型分析的高龄孕妇314例，按预产期年龄分为35～39岁组和≥40岁组；按血清学筛查情况分为血清学筛查低危组、血清学筛查高危组和未做血清学筛查组，分析各组胎儿染色体异常率。结果胎儿染色体异常率4．14％（13/314）。≥40岁组胎儿染色体异常率13．21％（7/53），高于35～39岁组2．30％（6/261）（ P＝0．001）。血清学筛查高危组胎儿染色体异常率7．69％（7/91），高于血清学筛查低危组0（0/64）（ P＝0．022）。结论对高龄孕妇进行血清学筛查，有助于减少介入性产前诊断率。Objective To investigate the incidence of chromosome abnormalities in advanced maternalage（AMA） ,and to investigate the value of prenatal screening in AMA . Methods Retrospective analysis of 314 cases of AMA which had invasive prenatal diagnosis .314 cases of AMA were divided into two groups according to expected date of childbirth age ：35~39 years old and older than 40 years old . And they were also divided into three groups according to serum screening ：low-risk serum screening group ,high-risk serum screening and without serum screeningand ,to analyze the percentage of fetal chro-mosome abnormalities in these groups . Results The percentage of fetal chromosomal abnormalities of 314 AMA was 4 .14% （13/314） . The percentage of fetal chromosomal abnormalities in AMA whose ma-ternal age older than 40 years old was 13 .21% （7/53） ,which was higher than that in AMA whose mater-nal age 35~39 years old 2 .30% （6/261） （P=0 .001） . In high-risk serum screening group ,the percent-age of fetal chromosome abnormalities was 7 .69% （7/91） ,which was higher than that in low-risk serum screening group 0 （0/64） （P=0 .022） . Conclusions Maternal prenatal screening tests could be applied in AMA .

关 键 词：孕妇 产前诊断 超声检查  产前 染色体畸变 妊娠中期 年龄因素 风险调节 回顾性研究 

分 类 号：R714.5[医药卫生—妇产科学]