干细胞治疗糖尿病难愈创面研究进展  

Advances in the research of treating refractory diabetic wounds with stem cells

作　　者：弓家弘[1] 陆树良[1] 

机构地区：[1]上海市创面修复研究中心,上海交通大学医学院附属瑞金医院上海市烧伤研究所,200025

出　　处：《中华烧伤杂志》2014年第6期518-521,共4页Chinese Journal of Burns

基　　金：国家重点基础研究发展计划（2012CB518105）;国家科技支撑计划（2012RA11 1 BOO）;国家自然科学基金（81071566）

摘　　要：随着社会人口老龄化程度的加剧，中国已成为全球糖尿病第一大国。糖尿病造成血管神经病变，使患者皮肤易受损，且创面往往反复发作、迁延不愈，形成顽固难愈性溃疡。糖尿病难愈创面的发生是多种内源性、外源性因素共同作用的结果，各致病因素彼此关联相互影响，构成了糖尿病创面复杂的病理生理事件，临床上尚缺乏切实有效的治疗方法。With the growth of aging society,China has become the country of population with the highest incidence of diabetes in the world.Diabetes leads to pathological changes in vascular and nervous system,rendering the diabetic skin fragile and hard to heal if wounded; in the end most diabetic wounds tend to become chronic skin ulcers.The refractory diabetic wound is the result of various endogenous and exogenous factors.It is a quite complicated pathophysiologic event which lacks an effective and specific therapeutic method in clinic.The use of stem cells could be a new approach of treating diabetic chronic wounds since they have a potential ability of self-renovation and multi-directional differentiation which will promote angiogenesis and wound healing process,thus be beneficial in the care of ischemia diseases of the lower limb.This article reviews basic theory of treating diabetic wound and the changes in microenvironment,and prompts many successful cases in curing refractory diabetic wounds.

关 键 词：糖尿病 干细胞 伤口愈合 干细胞龛 

分 类 号：R587.2[医药卫生—内分泌]