2型糖尿病肾病的危险因素分析  

Analysis of risk factors in patients with type 2 diabetic nephropathy

作　　者：戴彧君 翁敏 

机构地区：[1]昆明医科大学第一附属医院肾内科,云南昆明650031

出　　处：《现代医药卫生》2015年第1期11-13,共3页Journal of Modern Medicine & Health

基　　金：云南省教育厅科学研究基金(2013J055)

摘　　要：目的探讨2型糖尿病肾病发生的危险因素。方法选择2013年11月至2014年3月在该院内分泌科、糖尿病科和肾内科确诊为2型糖尿病肾病早期和临床期的122例患者为研究对象,根据尿微量清蛋白/尿肌酐比值（UACR）将其分为早期糖尿病肾病组（UACR 30-300 mg/g）62例和临床期糖尿病肾病组（UACR〉300 mg/g）60例。比较两组患者年龄、糖尿病病程、WHR、BMI、FPG、2h PG、Hbg、前清蛋白（PA）、Hb A1c、血浆清蛋白（ALB）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）、BUN、Cr及Cys C等指标。采用logistic回归分析2型糖尿病肾病与各因素的相关性。结果两组患者糖尿病病程、Hbg、ALB、TC、Cr、Cys C、BUN比较,差异均有统计学意义（P〈0.05）。logistic回归分析结果显示,糖尿病病程、TC、Cr及Cys C是糖尿病肾病发生与否的独立危险因素（OR=1.225、1.715、1.040、29.218,P〈0.05）。结论早期或临床期糖尿病肾病的发生及其严重程度与糖尿病病程、Cys C、Cr及TC独立相关,重视对糖尿病肾病相关因素的监测与评价有助于糖尿病肾病的预防和治疗。Objective To approach risk factors of the type 2 diabetic nephropathy（T2DN）. Methods A total of 122 patients diagnosed T2 DN from Department of Endocrinology,Department of Diabetes mellitus and Department of Nephrology from December 2013 to March 2014 were divided into the early DN group,62 persons（UACR：30-300 mg/g） and the clinic DN group,60persons（UACR〉300 mg/g） depending on the levels of urinary albumin to creatinine ratio（UACR）. It was compared the age,duration of diabetes（DOD）,WHR,BMI,FPG,2h PG,Hbg,PA,Hb A1 c,ALB,TG,TC,LDL-C,UA,BUN,Cr,Cys C. Logistic regression analysis was adopted to analyze the relationship between the T2 DN and various factors. Results There were statistically sig nificant differences in course of disease DOD,ALB,TC,Cr,Cys C and BUN between the two groups（P〈0.05）. Logistic regression analysis demonstrated that TC、Cr and Cys C were the independent risk factors（OR=1.225,1.715,1.040,29.218,P〈0.05）. Conclusion A close correlation exists between the occurrence and severity degree of the early or clinic DN and the independent risk factors of Cys C and TC. Monitoring and evaluating systemic factors is beneficial to prevention and treatment of DN.

关 键 词：糖尿病 2型 糖尿病肾病 肾疾病 半胱氨酸蛋白酶抑制剂 危险因素 

分 类 号：R587.2[医药卫生—内分泌]