PS/PSGL-1在冠心病合并颈动脉粥样斑块痰瘀互阻证中的作用  

Effects of PS/PSGL-1 in Phlegm and Blood Stasis of Coronary Heart Disease Patients with Carotid Artery Plaque

作　　者：范金茹[1] 那奕文[1] 刘小瑗[1] 陈彤[1] 肖正文[1] 戴冰[1] 王建湘[1] 王美香[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中华中医药学刊》2015年第1期104-107,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：湖南省教育厅重点项目(11A085)

摘　　要：目的:检测颈动脉内-中膜厚度(IMT)、斑块指数(Crouse积分)以及血清P-选择素(PS)、血清P-选择素糖蛋白配体1(PSGL-1)水平,探讨血小板-白细胞相互反应在冠心病合并颈动脉斑块痰瘀互阻证中的临床意义。方法:冠心病合并颈动脉粥样硬化患者80例(观察组),按照中医辨证分型分为痰瘀互阻证组、非痰瘀互阻证组,健康人30例(对照组),分别检测3组血清PS、PSGL-1水平与IMT、Crouse积分。结果:(1)观察组IMT、Crouse积分、PS、PSGL-1均明显高对照组(P<0.01);痰瘀互阻证组IMT、Crouse积分、PS、PSGL-1明显高于非痰瘀互阻证组(P<0.01)。(2)PS和PSGL-1的表达呈正相关性(r=0.714,P<0.01)。血清PS与IMT、Crouse积分呈正相关(P<0.01)。血清PSGL-1含量与IMT、Crouse积分亦呈正相关(P<0.05,P<0.01)。(3)冠脉造影结果中病变分支越多,PS、PSGL-1的水平越高(P<0.01,P<0.05)。结论:(1)颈动脉IMT及斑块积分可反映冠状动脉粥样硬化的程度。(2)PS、PSGL-1在冠心病合并颈动脉斑块发病过程中具有重要意义,可能与痰瘀互阻的实质存在一定关系。Objective ： To test the levels of IMT, Crouse scorings, PS and PSGL - 1 to explore the clinical significance ofthe platelet- leukocyte effects in patients with CHD and carotid atherosclerosis phlegm and blood stasis. Methods ：80 ca-ses met TCM syndrome diagnostic criteria,30 cases in line with the diagnostic criteria of phlegm and blood stasis and 50cases in line with the diagnostic criteria of non - phlegm and blood stasis. We detected the levels of serum PS ,PSGL - 1and IMT integral, Crouse integral in the healthy people and patients with CHD and carotid atherosclerosis. Results： （ 1 ）The IMT integral, Crouse integral, the serum levels of PS and PSGL - 1 in the observation group were significantly higherthan those of the control group and the difference was statistically significant （P 〈 0.01 ）. The IMT integral, Crouse inte-gral, PS and PSGL - 1 in phlegm and blood stasis group were also significantly greater than those of non - phlegm andblood stasis group （P 〈 0.01 ）. （2）The expression of PS and PSGL- 1 was positively correlated （r = 0. 714, P 〈0.01 ）. The serum levels PS,IMT integral and Crouse integral were positively correlated （P 〈0.01 ,P 〈0.01 ）. The ser-um PSGL -1 contents were also positively with the IMT integral and Crouse integral （P 〈 0.05 ,P 〈 0.01 ）. （3）With theincrease in the branch of lesions in the coronary angiography results, the levels of PS andPSGL - 1 gradually increased （P〈0.01 ,P 〈0.05）. Conclusion：The IMT and Crouse integral can reflect the extent of coronary atherosclerosis. PS andPSGL - 1 levels in coronary heart disease patients with carotid atherosclerosis are higher than those in normal people, andrelated with the pathogenesis of phlegm and blood stasis syndrome.

关 键 词：冠心病 颈动脉斑块 痰瘀互阻证 冠脉造影 PS PSGL-1 IMT Crouse积分 

分 类 号：R541.4[医药卫生—心血管疾病]