骨微循环内皮细胞在激素性股骨头坏死发病机制的作用研究进展  

Advance in effect of bone microvascular endothelial cells on pathogenesis of corticosteroid induced osteonecrosis of femoral head

作　　者：路玉峰[1,2] 郭万首[1,2] 程立明[1] 

机构地区：[1]中日友好医院骨关节外科,北京100029 [2]北京协和医学院研究生院,北京100730

出　　处：《中国矫形外科杂志》2015年第1期47-51,共5页Orthopedic Journal of China

基　　金：国家自然科学基金资助项目(编号:81273972)

摘　　要：大剂量糖皮质激素的使用是我国非创伤性股骨头坏死的主要原因,其确切的发病机制至今仍不明确,近期国内外研究认为股骨头内部骨微血管内皮细胞的损伤可能在股骨头内骨细胞及骨髓坏死的过程中扮演着重要的作用。微血管内皮细胞损伤不仅可以造成局部的凝血活性增高,形成微血栓,局部血管闭塞,导致支配区域股骨头坏死,而且损伤的微血管内皮细胞产生了大量的活性氧,减少了舒血管物质的合成,进一步加剧了内皮细胞本身的损伤及骨细胞、骨髓坏死。High- dose corticosteroid usage is the main cause of non- traumatic osteonecrosis of femoral head in our country. The clear pathogenesis is still unknown up to now. Recent study at home and abroad showed the damage of bone microvascular endothelial cells of femoral head had played a great role on the progression of bone cells and bone marrow necrosis. The injury of microvascular endothelial cells result in not only regional hypercoagulation,microthrombus formation,followed by ischemia and infarction in the femoral head,but also overproduction of reactive oxygen species as well as reduction of vasoactive substance synthesis,which further aggravate the injury of microvascular endothelial cells and necrosis of bone cells,bone marrow.

关 键 词：糖皮质激素 股骨头 内皮细胞 

分 类 号：R681.8[医药卫生—骨科学]