PET/CT引导低分割放疗治疗老年晚期非小细胞肺癌临床观察  

Clinical observation of hypofractionated high- dose radiotherapy treatment in PET/ CT simulation for elderly advanced non- small- cell lung cancer

作　　者：李小龙[1] 党亚正[1] 陆婉玲[1] 马玉新[1] 

机构地区：[1]解放军第323医院放疗中心,陕西西安710054

出　　处：《现代肿瘤医学》2015年第2期216-219,共4页Journal of Modern Oncology

摘　　要：目的:探讨在PET/CT引导下低分割放疗治疗老年晚期非小细胞肺癌的临床疗效。方法:收集采用PET/CT定位,接受胸部放疗老年晚期非小细胞肺癌23例,单次分割剂量2.5Gy,5次/周,总剂量35Gy-55Gy。结果:随访2-24个月,随访率1 0 0%;放射性食管炎发生率4 3.5%,Ⅰ、Ⅱ级放射性肺炎发生率21.7%;肺部病灶近期疗效:CR 17.4%、PR 52.2%、NC 17.4%、PD 13.0%;1年生存率47.8%,2年生存率8.7%。结论:PET/CT引导下低分割三维适形放疗治疗老年晚期非小细胞肺癌疗效确切,毒副反应尚可耐受。Objective：To investigate the clinical efficacy of hypofractionated high-dose radiotherapy treatment in PET/CT simulation of elderly advanced non-small-cell lung cancer.Methods：To analyze the effect of PET/CT simulation and chest radiation therapy for 23 elderly advanced non-small cell lung cancer cases.Dose fractionation 2.5Gy/d,5f/w,total dose 35Gy-55Gy.Results：Followed up for 2-24 months,follow-up rate was 100％.Radiation esophagitis incidence was 43.5％.Radiation pneumonia rate was 21.7％.Short term efficacy：CR 17.4％,PR 52.2 ％,NC 17.4％,PD 13.0％.1-year survival rate was 47.8％,2-year survival rate was 8.7％.Conclusion：Curative effect of three-dimensional conformal hypofractionated high-dose radiotherapy with PET/CT simulation on non-small cell lung cancer patients is definitely,radiation side effects can be tolerated.

关 键 词：晚期非小细胞肺癌 低分割 PET/CT 老年人 

分 类 号：R734.2[医药卫生—肿瘤]