耐多药肺结核病治疗方案中使用莫西沙星的临床效果  

Clinical effect of applying moxifloxacin in treatment scheme for multi-drug resistant tuberculosis

作　　者：吴颖[1] 

机构地区：[1]沈阳市胸科医院四病房结核内科,110044

出　　处：《中国现代药物应用》2015年第3期7-8,共2页Chinese Journal of Modern Drug Application

摘　　要：目的对比分析耐多药肺结核病治疗方案中使用莫西沙星和左氧氟沙星的临床效果。方法 48例耐多药肺结核病患者分为两组,即莫西沙星组24例和左氧氟沙星组24例,两组患者均以对氨基水杨酸异烟肼片、乙胺丁醇、吡嗪酰胺和丙硫异烟胺为基础抗结核方案,左氧氟沙星组联合应用左氧氟沙星片,莫西沙星组联合应用莫西沙星片,治疗12个月观察疗效和不良反应。结果治疗后莫西沙星组总有效率为91.7%,高于左氧氟沙星组的75.0%,差异有统计学意义(P<0.05);用药期间两组胃肠道反应、皮疹、肝功能异常、白细胞减少等不良反应发生率(29.2%VS 25.0%)比较,差异无统计学意义(P>0.05)。结论在耐多药肺结核病治疗方案中莫西沙星的疗效明显优于左氧氟沙星。Objective To compare and analyze clinical effects of applying moxifloxacin and levofloxacin in the treatment scheme for multi-drug resistant tuberculosis. Methods A total of 48 patients with multi-drug resistant tuberculosis were divided into two groups, as moxifloxacin group with 24 cases and levofloxacin group with 24 cases. Both groups received basic antituberculous scheme by isoniazid aminosalicylate tablets, ethambutol, pyrazinamide, and protionamide. The levofloxacin group was treated by additional levofloxacin tablets, and the moxifloxacin group received additional moxifloxacintablets. Curative effects and adverse reactions were observed after 12 months of treatment. Results The total effective rate after treatment of the moxifloxacin group was 91.7%, which was higher than 75.0%of the levofloxacin group, and the difference had statistical significance （P0.05）. Conclusion Moxifloxacin has remarkably better effect than levofloxacin in the treatment scheme for multi-drug resistant tuberculosis.

关 键 词：耐多药肺结核病 莫西沙星 左氧氟沙星 疗效 不良反应 

分 类 号：R521[医药卫生—内科学]