研究血浆氮末端脑钠肽前体水平与慢性肺心病肺动脉高压的相关性  

Correlation Between Plasma N-brainnatriuretic Peptide Precursor and Pulmonary Hypertension In Patients with chronic cor Pulmonale

作　　者：吴艳[1] 汪家坤[1] 赵滢寅[1] 

机构地区：[1]南京医科大学附属无锡市人民医院呼吸科,江苏无锡214023

出　　处：《河南中医》2014年第B11期341-342,共2页Henan Traditional Chinese Medicine

摘　　要：目的探讨并研究血浆氮末端脑钠肽前体水平与慢性肺心病肺动脉高压的相关性.方法：慢性肺心病肺动脉高压患者100 例,采用超声心动图测量所有患者的肺动脉收缩压（PASP）,根据测定的PASP 值大小分为重度PAH 组、中度PAH 组、轻度PAH 组及正常PAH 对照组.并检测血浆NT-ProBNP 值分析与肺动脉高压的关系.结果：肺动脉高压与NT-ProBNP 水平密切相关,重度PAH 组、中度PAH 组、轻度PAH 组的NT-ProBNP 水平明显高于对照组患者,组间对比差异具备统计学意义（P〈0.05）.结论：临床检测血浆氮末端脑钠肽前体水平可作为判断肺动脉高压的参考指标.Objective to investigate and study the plasma n- terminal brain natriuretic peptide precursor levels and the correlation of chronic cor pulmonale pulmonaryhypertension.Methods： 105 cases of patients with chronic cor pulmonale pulmonary hypertension, all are measured with echocardiography in patients with pulmonary artery systolicpressure （PASP）, according to the size of PASP value of determination of divided into severe PAH group, moderate PAH, mild PAH group and normal PAH in the control group. Anddetect the plasma NT - ProBNP value analysis and the relationship between pulmonary hypertension. Results： pulmonary hypertension and closely related to the level of the NT -ProBNP severe PAH, moderate PAH group, mild levels of NT - ProBNP PAH group was obviously higher than that of control group patients, comparing differences between groupshave statistical significance （P 〈 0.05）. Conclusion： clinical n terminal brain natriuretic peptide precursor test can be used as reference indexes of pulmonary hypertension.

关 键 词：血浆氮末端脑钠肽前体 慢性肺心病 肺动脉高压 

分 类 号：R322.3[医药卫生—人体解剖和组织胚胎学]