胰高血糖素样肽-2对肝硬化大鼠肠道屏障功能的保护作用  

作　　者：王向东[1] 廖群纷[1] 夏守国[1] 

机构地区：[1]四川省科学城医院,四川绵阳621000

出　　处：《中医学报》2014年第B12期396-396,共1页Acta Chinese Medicine

摘　　要：目的探讨胰高血糖素样肽-2（GLP-2）对肝硬化大鼠肠道屏障功能的保护作用.方法：16 只雌性SD 大鼠自由饮用0.01%的二乙基亚硝胺（四川省农业科学研究院农药研究所提供）2 个月,造成大鼠肝硬化模型,然后随机分为肝硬化对照组和肝硬化治疗组,每组8 只,治疗组每天腹腔注射GLP-2 250μg/kg.对照组注射等体积的生理盐水.共2 周.然后检测血浆内毒素（LPs）、肿瘤坏死因子（TNF-a）、白介素-6,8（IL-6,IL-8）的变化.结果：肝硬化治疗组血浆内毒素（LPs）、肿瘤坏死因子（TNF-a）、白介素-6,8（IL-6,IL-8）明显低于肝硬化对照组（p〈0.05）.结论：胰高血糖素样肽-2 对肝硬化大鼠的肠道屏障功能有明显的保护作用.ObjectiveTo study the protection of glucagons-like peptide-2（GLP-2）on intestinal barrier function in liver cirrhosis rat model. Methods：16 SD female rats withliver cirrhosis which were induced by diethylnitrosamine were randomly assigned to two groups： cirrhosis control group and cirrhosis treatment group, there were 8 rats in each group.GLP-2（250μg/kg ）was injected intraperitoneally every day for 2weeks in cirrhosis treatment group and the equal volume of NS was injected intraperitoneally in cirrhosis control group.Then the levels of LPs, TNF-a, IL-6 and IL-8 were tested in all rats. Results：Compared with cirrhosis control group, the levels of LPs, TNF-a, IL-6 and IL-8 were significantly low（p〈0.05）. Conclusion：Glucagons-like peptide-2（GLP-2）has protection on intestinal barrier function in liver cirrhosis rat model.

关 键 词：胰高血糖素样肽-2 肝硬化大鼠 肠道屏障功能 内毒素 肿瘤坏死因子 

分 类 号：R657.31[医药卫生—外科学]