中药离子导入敷贴防治小儿反复呼吸道感染方案比较  

Clinical Efficacy Analysis of Herbal Ion Application and Penetration Therapy for Prevention and Treatment of Recurrent Respiratory Tract Infection in Children

作　　者：宣小平[1] 霍莉莉[1] 虞坚尔[2] 夏以琳[2] 陈莹[2] 李华[3] 卢伯良 

机构地区：[1]上海市中西医结合医院,上海200082 [2]上海中医药大学附属上海市中医医院儿科,上海200071 [3]上海市嘉定区中医医院,上海201800 [4]上海市松江区方塔中医医院,上海201600

出　　处：《广州中医药大学学报》2014年第6期915-920,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：上海市卫生局科研基金课题(编号:20090178);上海市卫生局中医药科研基金课题(编号:2009s011);同济大学"中医大师传承人才培养项目"【国中医药函2008(185)】

摘　　要：【目的】比较夏季三伏、冬夏伏九2种中药离子导入敷贴方案防治小儿反复呼吸道感染(recurrent respiratory tract infection,RRTI)的临床疗效。【方法】采用多中心、随机对照、重复测量、单盲设计,临床收集240例反复呼吸道感染患儿,随机分为三伏组和伏九组各120例,借助离子导入仪,进行中药穴位敷贴,治疗1年,再随访1年,观察2组治疗前后呼吸道感染的发病次数、发作期病程、中医症候,并分时间点检测唾液分泌型免疫球蛋白A(sIgA)。【结果】(1)伏九组临床疗效优于三伏组,2组比较差异有统计学意义(P<0.05)。(2)2组均可减少发病次数,缩短发作期病程,改善中医症候(P<0.05),其中伏九组较三伏组作用更显著(P<0.05)。(3)伏九组不同时间点sIgA呈持续上升趋势,三伏组不同时间点sIgA呈轻度下降趋势(P<0.05)。【结论】中药离子导入敷贴防治小儿反复呼吸道感染,冬夏伏九方案优于夏季三伏方案,值得临床继续探讨。Objective To compare the clinical efficacy of herbal ion application and penetration therapy applied in the dog days, or in both of the dog days and coldest days for the treatment of recurrent respiratory tract infection （RRTI） in children. Methods This intervention was designed as a multi-center, randomized, single-blind, repeated-measurement design. A total of 240 RRTI children were randomly divided into Sanfu group （N=120, herbal ion application and penetration therapy applied in the dog days） and Fujiu group （N=120, herbal ion application and penetration therapy applied in both of the dog days and coldest days）. Each group was treated for one year and then was followed up for one year. Before and after the treatment, we observed the frequency of respiratory tract infection, the period of onset, signs and symptoms of traditional Chinese medicine （TCM）, and detected the salivary secretory immunoglobulin A （sIgA） at different time points. Results （1） The therapeutic effect of Fujiu group was better than that of Sanfu group, and the difference was significant （P〈0.05）. （2） The frequency of respiratory tract infection was reduced, the period of onset was shortened, and TCM signs and symptoms were improved in both groups, and the effect of Fujiu group was superior to that of Sanfu group （P〈0.05）. （3） Salivary sIgA showed a continuous upward trend in Fujiu group while a mild downward trend in Sanfu group at different time points （P〈0.05）. Conclusion Herbal ion application and penetration therapy applied in both of the dog days and coldest days shows better effect for the treatment of children RRTI than that applied only in the dog days.

关 键 词：反复呼吸道感染/穴位疗法 冬病夏治 中药离子导入疗法 分泌型免疫球蛋白A 

分 类 号：R725.6[医药卫生—儿科]