荷S_(180)小鼠血清MDA、SOD和GSH-PX的变化及无花果多糖对其影响  

The Changes of Blood Serum MDA, SOD and GSH-PX in Mice S180-bearing and the Effects of FCPS on Its Change

作　　者：朱凡河[1] 王绍红[1] 徐丽娟[2] 

机构地区：[1]济宁医学院药理教研室,山东济宁272100 [2]金乡县人民医院,山东金乡272103

出　　处：《中国民族民间医药》2002年第4期231-232,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的 :观察无花果多糖对荷瘤小鼠血清丙二醛、超氧化物歧化酶和谷光甘肽过氧化物酶的影响。方法 :以荷S1 80 实体瘤小鼠为模型 ,灌胃给药 ,连续 10d ,测定小鼠血清中SOD、GSH -PX的活性及MDA的含量。结果 :无花果多糖可提高荷瘤小鼠血中抗氧化酶的活性 ,降低脂质过氧化物的含量。结论 :无花果多糖的抗瘤作用可能与提高SOD、GSH -PX活性 。Objective:To investigate the changes of malondialdehyde(MDA),supeeroxide dismutase(SOD)and glutathione peroxidase(GSH-PX)activity in blood serum of S180-bearing mice,and the effects of FCPS on them.Methods:The model of S180-bearing mice was estiblished,FCPS were administrated by oral route(200.400mg/kg)for 10d,the content of MDA,SOD,GSH-PX were measured in blood serm of S180-bearing mice treated with and without FCPS.Result:The S180-bearing mice had higher levels of MDA than that of normal controls,wheresa the activity of SOD and GSH-PX in S180-bearing mice group were lower in comprision with control group,FCPS could enhance SOD and GSH-PX activity,and decrease MDA content of blood serum in S180-bearing mice.Conclusion:The anti-tumor effect of FCPS might relevent to increasing the activity of SOD,GSH-PX and decreasing the leves of MDA in S180-bearing mice.

关 键 词：荷S180小鼠 血清MDA GSH-PX 无花果多糖 脂质过氧化 

分 类 号：R273[医药卫生—中西医结合] R285.5[医药卫生—中医肿瘤科]