抗结核药物不良反应50例临床分析  

作　　者：李银鹏[1] 李建民[1] 

机构地区：[1]中国石油天然气集团公司中心医院,河北廊坊065000

出　　处：《医学美学美容（中旬刊）》2014年第10期761-762,共2页

摘　　要：目的探讨抗结核药物不良反应的一般规律为临床提供防治对策。方法收集我科2009年1月至2013年12月因抗结核药物所致不良反应50例患者进行临床分析。结果抗结核药物所致不良反应多发生在用药15天以内，以肝功能损害最常见，其次为皮疹，引起肝功能损害常见的药物为利福平及吡嗪酰胺，引起皮疹常见的药物为利福平及异烟肼。结论采取个体化治疗，合理选择抗结核药物，可以把不良反应降到最低限度。Objective To-explore the general regularity of the side - effect of anti - tuberculosis drug and to provide the prophylactico - therapeutic measures for clinic. Methods Fifty ca- ses of pulmonary tuberculosis with side - effect during January 2009 to Desember 2013 were enroUed and their clinical data were analyzed. Results Side - effect mostly occurred within 15 days since taking medicine, in which the occurrence of liver function damage is the most common, and then the skin rash. Hypefunction of liver was mostly caused by rifampin（RFP） and pyrazimamide （PZA）. Skin rash was mostly caused by , RFP and isoniazid（INH）. Conclusion Adopting individualization treatment and choosing anti -tuberculosis drug reasonably can reduce theside - effect to the minimum.

关 键 词：肺结核 抗结核药物 不良反应 

分 类 号：R726.12[医药卫生—儿科]