山西省艾滋病抗病毒治疗死亡病例流行病学分析  

Epidemiological analysis of AIDS mortality following antiretroviral therapy in Shanxi Province

作　　者：原琛利[1] 穆生财[1] 薛子东[1] 

机构地区：[1]山西省疾病预防控制中心性病艾滋病防控科,山西太原030012

出　　处：《中华疾病控制杂志》2014年第12期1184-1186,共3页Chinese Journal of Disease Control & Prevention

基　　金：中国全球基金艾滋病项目(CHN-304-G03-H)

摘　　要：目的分析山西省艾滋病抗病毒治疗死亡病例的治疗生存时间及其影响因素,为进一步降低艾滋病病死率提供合理建议。方法利用国家统一使用的抗病毒治疗信息系统,收集山西省2004年6月～2013年12月之间治疗死亡病例的数据资料,并用SPSS 18.0软件进行分析。结果共收集死亡病例315例,平均年龄（43.73±12.65）岁,男女性别比1.7∶1,已婚或同居占69.21%（218/315）,经血传播途径占58.10%（183/315）,73.33%（231/315）的病例死于艾滋病相关疾病,64.13%（202/315）的病例接受治疗时已进入艾滋病WHO临床Ⅲ期和Ⅳ期;基线CD4＋T淋巴细胞计数中位数为44个/μL,52.15%（158/303）病例的CD4＋T淋巴细胞计数小于50个/μL;死亡病例治疗生存时间中位数218天,37.78%（119/315）的病例在抗病毒治疗开始的3个月内死亡。影响死亡病例治疗生存时间的因素有：艾滋病WHO临床分期、基线CD4＋T淋巴细胞计数和传播途径。结论山西省艾滋病患者开始治疗时CD4＋T淋巴细胞水平较低及艾滋病临床感染分期较高是造成患者死亡的主要原因,建议进一步加大检测覆盖面同时提倡早期治疗。Objective To analyze the survival time and factors of deaths who patients received highly active antiretroviral therapy （HAART） and to provide information for reduction of AIDS death rate. Methods The data of patient＇ s death who received HAART in Shanxi Province were collected by China Information＇System for Diseases Control and Prevention from 2004 to 2013, and were analyzed by SPSS 18.0 software. Results 315 patient＇ s death were retrieved. The average age was 43.73 ± 12. 65 years old. The ratio of male to female was 1.7 ： 1. 69. 21% of patients were married or cohabited. 58.10% of patients were infected with HIV through blood transmission. 73.33% of them died of AIDS related disease. 64. 13% of patients had entered the AIDS clinical WHO stage Ⅲ or IV for receiving treatment. The median of baseline CD4^＋ cell counts was 44 counts/μL and the median of the interval between the time of HIV confirmation and HAART treatment was 218 days. Factors affecting death patients survival time were AIDS clinical staging of WHO, baseline CD4^＋ cell counts and the infection routes. Conclusions The lower baseline CD4^＋ cell counts and the higher WHO stages are the main factors related to death of AIDS patients received HARRT.

关 键 词：获得性免疫缺陷综合征 抗病毒治疗 流行病学研究 

分 类 号：R512.91[医药卫生—内科学]