替罗非班在急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗中的应用效果分析  

Application Effect of Tirofiban on Percutaneous Coronary Intervention in Patients with Acute ST-segment Elevation Myocardial Infarction

作　　者：李建民[1] 殷屹刚 王如珠[1] 林杰[1] 王斌[1] 王叶宝[1] 

机构地区：[1]江苏省泰州市人民医院心内科,225300

出　　处：《实用心脑肺血管病杂志》2014年第10期42-43,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的分析替罗非班在急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗(PCI)中的应用效果。方法选取我院2011年1月—2014年1月收治的急性ST段抬高型心肌梗死患者98例,随机分为对照组48例和观察组50例。两组患者入院后均给予常规药物治疗和PCI,观察组患者在此基础上给予替罗非班。观察两组患者术后即刻TIMI血流改善率、ST段回落率,术后48 h主要心血管不良事件(MACE)发生率、出血事件发生率,术后6个月左室射血分数(LVEF)。结果观察组患者术后即刻TIMI血流改善率、ST段回落率高于对照组(P<0.05);两组患者术后48 h MACE发生率、出血事件发生率、术后6个月LVEF比较,差异均无统计学意义(P>0.05)。结论在急性ST段抬高型心肌梗死患者PCI中应用替罗非班安全有效,其可有效改善患者TIMI血流及心肌灌注,且并不增加MACE、出血事件发生风险。Objective To analyze the application effect of tirofiban on percutaneous coronary intervention（ PCI） in patients with acute ST- segment elevation myocardial infarction. Methods From January 2011 to January 2014,a total of 98 patients with acute ST- elevation myocardial infarction in our hospital were selected and randomly divided into control group（ n =48） and observation group（ n = 50）. Both groups given routine treatment and PCI,observation group given extra tirofiban.TIMI blood flow improvement rate after operation,ST- elevation fall back rate,incidence of major adverse cardiac events（ MACE） after operation,incidence of hemorrhage,left ventricular ejection fraction（ LEVF） after 6 months of operation between the two groups were compared. Results TIMI blood flow improvement rate after operation and ST- elevation fall back rate of observation group were higher than those of control group（ P〈0. 05）,while there was no significant differences of incidence of MACE after operation,incidence of hemorrhage,LEVF after 6 months of operation between the two groups（ P〈0. 05）.Conclusion Tirofiban is effective and safe in PCI in patients with acute ST- segment myocardial infarction,which can improve the TIMI blood flow and myocardial perfusion,without increasing the risk of MACE and hemorrhage.

关 键 词：心肌梗死 血管成形术 经腔 经皮冠状动脉 替罗非班 

分 类 号：R542.22[医药卫生—心血管疾病]