2-甲氧基-3-溴-5-硝基苯基苄基醚的合成方法研究  

Synthesis of 3-bromo-2-methoxy-5-nitrophenyl benzyl ether

作　　者：杨智麟 刘许歌[1] 沈悦海[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2014年第6期415-419,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：国家自然科学基金(81260351);云南省自然科学基金(2010ZC016)

摘　　要：研究了安莎霉素类天然产物reblastatin芳核片段2-甲氧基-3-溴-5-硝基苯基苄基醚的合成方法.该合成路线的关键步骤是苯甲醛中间体的Baeyer-Villiger反应,此反应易生成羧酸副产物.通过对反应试剂和操作的优化,以84%的高产率获得了预期产物酚.该路线以5步直线步骤和33%的总收率实现了2-甲氧基-3-溴-5-硝基苯基苄基醚的制备.A synthesis of 3 - bromo - 2 - methoxy - 5 - nitrophenyl benzyl ether, the aromatic fragment of ansamy- ein natural product reblastatin, was developed. The key reaction in this synthesis was a Baeyer - Villiger reaction of a benzaldehyde intermediate, as the undesired benzoic acid could be the major product in certain cases. After the optimization of reagents and operation, the desired phenol intermediate was obtained in 84% yield. This approach- produced 3 -bromo -2 -methoxy -5 -nitrophenyl benzyl ether in 5 linear steps and 33% overall yield.

关 键 词：2-甲氧基-3-溴-5-硝基苯基苄基醚 Baeyer-Villiger反应 Reblastatin 

分 类 号：O621.34[理学—有机化学]