响应面法优化羟基香茅醛1,2-丙二醇缩醛的合成  

Optimization of Synthesis of Hydroxyl Citronella Aldehyde-1,2-propanediol Acetal Using Response Surface Method

作　　者：蔡美萍[1,2] 范国荣[1] 陈尚钘[1] 陈金珠[1] 王宗德[1] 

机构地区：[1]江西农业大学林学院,江西南昌330045 [2]正邦集团江西新世纪民星动物保健品有限公司,江西南昌330096

出　　处：《林产化学与工业》2014年第6期124-128,共5页Chemistry and Industry of Forest Products

基　　金：国家林业公益性行业科研专项经费项目(201304602);江西省主要学科学术和技术带头人培养计划(20133BCB22004);江西省科技支撑计划项目(20132BBF60057)

摘　　要：通过单因素试验,确定对目标产物产率影响最显著的3个因素分别为羟基香茅醛与1,2-丙二醇物质的量比、反应温度和反应时间。根据Central Composite Design试验设计原理,采用3因素3水平的响应面法,以目标产物产率为响应值,分析各个因素的显著性和交互作用,结果表明最佳合成条件为羟基香茅醛与1,2-丙二醇物质的量比为1∶3.5,反应温度为38℃,反应时间4.4 h,羟基香茅醛与甲苯物质的量比1∶2-1∶2.5,此条件下目标产物产率为89.76%。On the basis of single factor experiments, the synthesis conditions of hydroxyl citronella aldehyde-1,2-propanediol acetal from hydroxycitronellal and 1,2-propylene glycol were optimized using response surface method （RSM）. The results of the single factor experiments showed that the most significant factors were the substance ratio of hydroxycitronellal to 1,2-propylene glycol, the reaction temperature and the reaction time. According to the experiment design principle of Central Composite Design, the response surface method of three factors with three levels were employed, and the yield of target compound in the reaction system were taken as the response value to analyze the significance and interaction of the various factors. The optimal synthesis conditions were substance ratio of hydroxycitronellal to 1,2-propylene glycol 1∶3. 5, reaction temperature 38 ℃, reaction time 4. 4 h, and substance ratio of hydroxycitronellal to toluene 1∶2 -1∶2. 5. Under the optimal conditions, the yield of target compound was 89. 76 %.

关 键 词：羟基香茅醛1  2-丙二醇缩醛 合成 响应面法 

分 类 号：TQ351[化学工程]