糖尿病中血管平滑肌细胞表型转化机制及中医药干预  

Phenotypic modulation of vascular smooth muscle cells in diabetes mellitus and intervention of traditional Chinese medicines

作　　者：毛晓东[1] 程卓安[1] 郑建普[1,2] 

机构地区：[1]上海中医药大学附属普陀医院实验中心,上海200062 [2]上海中医药大学附属普陀医院心内科,上海200062

出　　处：《中国中药杂志》2014年第24期4723-4727,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31340006);上海市自然科学基金项目(13ZR1437600);上海中医药大学中医学一流学科建设项目(ZYD201302);普陀医院科研基金项目(2013SR117 I;2013GQ004 I;2013QK01)

摘　　要：血管平滑肌细胞(vascular smooth muscle cells,VSMC)的增殖和迁移是动脉粥样硬化斑块形成、高血压等糖尿病血管并发症的共同病理特征,而VSMC表型转化是VSMC增殖和迁移的基础,因此研究糖尿病中VSMC表型调节及机制,对防治糖尿病血管并发症具有重要意义。该文拟介绍VSMC表型转化机制及糖尿病中VSMC表型的改变,并综述中药复方及单体干预VSMC表型转化的研究进展,为糖尿病血管并发症的中医药防治提供参考。Proliferation and migration of vascular smooth muscle cells （VSMC） are common pathological features of diabetic vascular complications,such as atherosclerosis and hypertension. Phenotypic modulation of VSMC is the basis for VSMC proliferation and migration. Therefore, studies on VSMC phenotypic modulation and its mechanisms in diabetes mellitus were of important significance to the prevention and therapy of diabetic vascular complications. This paper introduces VSMC phenotypic modulation and the underlying mechanisms in diabetes mellitus, and summarizes advance of studies on traditional Chinese medicine intervention upon VSMC phenotypic modulation, so as to provide reference for preventing and treating diabetic vascular complications with traditional Chinese medicines.

关 键 词：糖尿病 血管平滑肌细胞 表型转化 血管并发症 中药 

分 类 号：R259[医药卫生—中西医结合]