疏肝理气法治疗糖尿病周围神经病变32例  

Liver-soothing Qi-regulating Method in the Treatment for 32 Cases of Diabetic Peripheral Neuropathy

作　　者：刘志伟[1] 安淑华[1] 孟宪杰[1] 叶春芳[1] 张丽华[1] 田丽[1] 马正云[1] 曹雪峰[1] 

机构地区：[1]唐山市人民医院内分泌科,河北唐山063000

出　　处：《西部中医药》2014年第12期57-59,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察疏肝理气中药治疗糖尿病周围神经病变的临床疗效。方法:将64患者随机分为治疗组、对照组各32例,2组患者均给予皮下注射胰岛素控制血糖,治疗组予疏肝理气中药内服,1剂/d,对照组予甲钴胺片500μg,3次/d,口服。2组均以治疗16周为1个疗程。观察2组治疗前后空腹血糖(FBG)、餐后2小时血糖(PBG)、甘油三酯(TG)、高敏C反应蛋白(CRP)、血浆内皮素(ET)及神经传导速度的变化,并计算治疗前后胰岛素抵抗指数(HOMA-IR)。结果:总有效率治疗组为91.0%,对照组为84.0%,2组比较差异有统计学意义(P<0.05)。FBG、PBG治疗后2组均明显降低(P<0.05),组间比较差异无统计学意义(P>0.05)。TG、ET、CRP、HOMA-IR治疗后治疗组明显下降(P<0.05),组间比较差异有统计学意义(P<0.05)。神经传导速度2组治疗前后组内比较差异显著(P<0.05),治疗组改善更明显(P<0.05)。结论:疏肝理气中药治疗糖尿病周围神经病变临床疗效显著,可提高患者神经传导速度。Objective： To observe curative effects of liver-soothing Qi-regulating method in treating diabetic peripheral neuropathy（DPN）. Methods： Sixty-four patients were randomized into the treatment group and the control group, they accepted subcutaneous injection of insulin to control blood glucose to fasting blood glucose（FBG）, the treatment group took the herbs of liver-soothing Qi-regulating, one dose each day, the control group were administered with mecobalamine tablets, 500μg, three times per day, orally. One course of the treatment was 16 weeks. The changes of FBG before and after treating, 2h postprandial blood glucose, glycerin trimyristate（TG）, high sensitivity C reactive protein（CRP）, endothelin（ET） and nerve conduction velocity（NCV） were observed,homestasis model of assessment for insulin resistance index（HOMA-IR） before and after treating was calculated.Results： Total effective rates of both groups were 91.0% and 84.0%, the difference between both groups was notable（P〈0.05）. FBG, PBG of both groups were decreased after treating（P〈0.05）, there was no difference between both groups（P〉0.05）. TG, ET, CRP, HOMA-IR of the treatment group were lowered obviously after treating（P〈0.05）, the difference was notable between both groups（P〈0.05）. The difference was significant in NCV between before and after treating（P〈0.05）, the improvement of the treatment group was more notable（P〈0.05）. Conclusion： Herbs of liver-soothing Qi-regulating could obtain better effects in treating DPN, and it could improve NCV of the patients.

关 键 词：糖尿病周围神经病变 疏肝理气 中药 

分 类 号：R587.1[医药卫生—内分泌]