Hβ分子筛催化合成2,3-无取代苯并呋喃的研究  

Synthesis of 2,3-unsubstituted benzo [b] furans via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals under the catalysis of Hβ zeolite

作　　者：孙楠[1] 黄鹏[1] 任鸿[1] 江晋[2] 沈振陆[1] 胡宝祥[1] 莫卫民[1] 胡信全[1] 

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014 [2]杭州中美华东制药有限公司,浙江杭州310011

出　　处：《浙江工业大学学报》2014年第6期621-626,659,共7页Journal of Zhejiang University of Technology

基　　金：国家自然科学基金资助项目(21376224);浙江省化学工程与技术重中之重一级学科开放基金资助项目(20130212)

摘　　要：以商品化的Hβ沸石分子筛为固体酸催化剂,通过（2,2-二乙氧基）乙基芳基醚的分子内环化制备了一系列2,3-无取代苯并呋喃类化合物,收率为61％～80％.此外,商品化的Hβ催化剂经过简单洗涤可直接重复使用.研究路线所使用的起始原材料廉价易得且来源丰富,反应操作简便,环境友好.A heterogeneous process for the preparation of 2,3-unsubstituted benzo[b]furans has been developed by the intramolecular cyclization of 2-aryloxyacetaldehyde diethyl acetals. Commercially available Hβ zeolite was found to be efficient in this cyclization reaction and could be reused for several times without obvious loss of catalytic ability. Under the optimal reaction conditions, a broad range of functionalized 2,3-unsubstituted benzo[b]furans could be facilely obtained in moderate to good yields. This newly developed method was economic, easy to operate and environmental-benign.

关 键 词：:2 3-无取代苯并呋喃 (2 2-二乙氧基)乙基芳基醚 Hβ沸石分子筛 非均相酸催化 

分 类 号：O626.4[理学—有机化学]