DNA氧化损伤与慢性阻塞性肺疾病关系的研究进展  

Research Progress of the Relationship between Chronic Obstructive Pulmonary Disease and DNA Damage

作　　者：许时丽 周玉生[1,2] 李荣[2] 盘捷[2] 

机构地区：[1]南华大学药物药理研究所,湖南省衡阳市421001 [2]南华大学附属第二医院药剂科

出　　处：《中国全科医学》2014年第33期4015-4017,共3页Chinese General Practice

摘　　要：慢性阻塞性肺疾病(COPD)是一种可以预防和治疗的疾病,其特点是气道的慢性炎症以及肺实质和肺泡结构的渐进破坏,引起不完全可逆的气流受限。COPD的发病是多种复杂机制相互作用的结果,如炎性反应、蛋白酶/抗蛋白酶失衡、氧化应激、DNA损伤、细胞凋亡、细胞衰老和细胞修复功能缺陷。本文对氧化应激引发的DNA氧化损伤与COPD的关系进行综述。Chronic obstructive pulmonary disease（ COPD） is a preventable and treatable disease,manifesting as airflow limitation caused by chronic inflammation of airways and progressive destruction of lung parenchyma and structure. The pathogenesis of COPD is resulted by a variety of complex mechanisms such as inflammation,protease / antiprotease imbalance,oxidative stress,DNA damage,apoptosis,cell senescence and cell repair defects. This paper reviews the relationship between oxidative DNA damage and chronic obstructive pulmonary disease.

关 键 词：肺疾病 慢性阻塞性 DNA 氧化性应激 综述 

分 类 号：R563[医药卫生—呼吸系统]