重组牛碱性成纤维细胞生长因子眼用凝胶和玻璃酸钠滴眼液治疗睑板腺异常相关干眼疗效比较  

Comparative Study of Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Sodium Hyaluronate Eye Drops for Treating Meibomian Gland Abnormality Related Dry Eye

作　　者：王雪飞 覃冬菊 李明哲 

机构地区：[1]上海市浦东医院,上海201399

出　　处：《中国药业》2014年第23期37-39,共3页China Pharmaceuticals

摘　　要：目的比较重组牛碱性成纤维细胞生长因子眼用凝胶和玻璃酸钠滴眼液对睑板腺异常相关干眼的治疗效果。方法将2012年3月至2013年8月收治的睑板腺异常相关干眼患者73例(73只眼),随机分为重组牛碱性成纤维细胞生长因子眼用凝胶组(观察组)和玻璃酸钠滴眼液组(对照组)。比较两组患者治疗前及治疗后15,30 d的临床症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠa)、角膜荧光素染色评分(FL)及睑板腺评分,统计治疗总有效率。结果两组治疗后30 d临床症状评分、BUT及FL评分均优于治疗前及治疗后15 d(均P<0.05);治疗后30 d,观察组临床症状评分、BUT及FL评分均优于对照组(均P<0.05);两组治疗前后SchirmerⅠa及睑板腺评分未见改善(均P>0.05)。观察组治疗总有效率明显高于对照组(P<0.05)。结论重组牛碱性成纤维细胞生长因子眼用凝胶和玻璃酸钠滴眼液均可改善患者的临床症状,延长泪膜破裂时间,修复角膜损伤,但前者疗效优于后者。两者对睑板腺功能障碍的改善作用均不佳,需配合其他药物治疗。Objective To investigate the efficacy of Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Sodium Hyaluronate Eye Drops for the treatment of meibomian gland abnormality related dry eye. Methods 73 patients（ 73 eyes） with meibomian gland abnormaly related dry eye in the department of ophthalmology of our hospital from March 2012 to March 2013 were randomly divided into the Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel group（ observation group） and Sodium Hyaluronate Eye Drops group（ control group）. And the clinical symptom score, tear film breakup time（ BUT）, Schirmer test（ Schirmer Ia）,corneal fluorescein staining score（ FL） and meibomian gland score before treatment and on 15,30 d after treatment were compared between the two groups. Results The clinical symptom scores, BUT and FL scores after 30 d treatment in the two groups were both better than those before treatment and after 15 d treatment（ all P〈0. 05）; the clinical symptom scores,BUT and FL scores after 30 d treatment in the observation group were better than those in the control group（ all P〈0. 05）; the Schirmer Ia and the meibomian gland score after treatment in the two groups had no improvement compared with before treatment（ all P〉0. 05）. The effective rate of the observation group was higher than that of the control group and the total effect had statistically significant difference between the two groups（ P〈0. 05）. Conclusion Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Sodium Hyaluronate Eye Drops can both improve the clinical symptoms,prolong the tear film BUT and repair corneal damage for treating meibomian gland abnormality related dry eye,but the former is more effective than the latter. The effects of both two methods for improving the meibomian gland dysfunction are poor,which needs to coordinated with other medication therapy.

关 键 词：重组牛碱性成纤维细胞生长因子眼用凝胶 玻璃酸钠滴眼液 睑板腺异常 干眼 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R988.1[医药卫生—药学]