复方小儿退热栓治疗小儿高热惊厥56例疗效及安全性观察  

Observation on Effect and Safety of Compound Pediatric Antifebrile Suppository in Treating Infantile Febrile Convulsion

作　　者：李华蓉[1] 李长金[1] 

机构地区：[1]重庆三峡中心医院儿童分院急诊科,重庆404000

出　　处：《中国药业》2014年第23期109-110,共2页China Pharmaceuticals

摘　　要：目的观察复方小儿退热栓治疗小儿高热惊厥的疗效及安全性。方法将112例患儿随机均分为2组,对照组予镇静、抗感染等对症处理,观察组在对照组基础上加用复方小儿退热栓治疗。结果对照组患儿治疗前平均惊厥次数为(4.3±1.8)次,治疗5 min后为(2.8±2.3)次(P<0.05)。观察组患儿治疗前平均惊厥次数为(4.2±2.0)次,治疗后5 min后为(1.1±2.1)次(P<0.05),且治疗5 min后平均惊厥次数较对照组明显减少(P<0.05)。与对照组相比,观察组患儿惊厥症状好转迅速,症状改善明显,患儿体温下降幅度超过1℃及住院治疗时间均明显缩短(P<0.05)。观察组患儿治疗显效率和总有效率明显高于对照组患儿(P<0.05)。两组患儿治疗过程中不良反应发生率比较未见明显差异(P>0.05)。结论联合复方小儿退热栓治疗小儿高热惊厥的疗效确切、稳定、安全,值得临床推广。Objective To observe the effect and safety of Compound Pediatric Antifebrile Suppository in treating infantile febrile convulsion. Methods 112 patients with infantile febrile convulsion were divided into 2 groups randomly. The control group was treated by the symptomatic treatment of sedation,anti- infection,etc.,while on this basis the observation group was added with Compound Pediatric Antifebrile Suppository. The curative effects and safety were observed and compared between the two groups. Results In the control group,the average convulsion times before treatment was（ 4. 3 ± 1. 8） times, which after 5 min treatment was（ 2. 8 ± 2. 3） times, showing the statistical difference between before and after treatment（ P〈0. 05）. In the observation group, the average convulsion times before treatment was（ 4. 2 ± 2. 0） times, which after 5 min treatment was（ 1. 1 ± 2. 1） times,showing the statistical difference between before and after treatment（ P〈0. 05）. At the same time the average convulsion times after 5 min treatment in the observation group were significantly decreased compared with the control group,the difference had statistical significance（ P〈0. 05）. Compared with the control group,the convulsion symptom in the observation was rapidly improved. In addition, the time of the body temperature decreased by 1 ℃ and the hospitalization time in the observation group were significantly shortened compared with the control group,the differences showed the statistical significance（ P〈0. 05）. The significantly effective rate and the total effective rate in the observation group were significantly higher than those in the control group with statistical differences（ P〈0. 05）. The occurrence rate of adverse reactions during treatment had no statistically significant difference between the two groups（ P〈0. 05）. Conclusion The combination treatment of Compound Pediatric Antifebrile Suppository for treating infantile febrile convulsion has definite effect with stability

关 键 词：小儿高热惊厥 复方小儿退热栓 疗效 安全性 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]