烧伤皮肤再生医疗技术治疗糖尿病足部溃疡疗效的系统评价  

Efficacy of MEBT/MEBO for Diabetic Foot Ulcers:A Systematic Review

作　　者：吴标良[1,2] 唐乾利[2] 冯烈[1] 李金桂[2] 王民登[2] 

机构地区：[1]暨南大学第一临床医学院,广东省广州市510632 [2]右江民族医学院附属医院

出　　处：《中国全科医学》2014年第32期3851-3854,共4页Chinese General Practice

基　　金：国家自然科学基金资助项目(81360547);广西自然科学基金重点项目(2013GXNSFDA019020)

摘　　要：目的系统评价烧伤皮肤再生医疗技术〔湿润暴露疗法/湿润烧伤膏(MEBT/MEBO)〕治疗糖尿病足部溃疡的疗效和安全性。方法计算机检索Medline、EMBase、Cochrane图书馆临床试验资料库、中国生物医学文献数据库、中国知网、维普数据库和万方数字化期刊群,并手工检索相关领域其他杂志,检索时间为数据库创建至2014年4月。纳入以糖尿病足患者为研究对象、比较MEBT/MEBO与其他创面治疗方法的随机对照试验(RCT)。评价纳入文献的质量,采用RevMan 5.1软件进行系统评价。结果共纳入10篇RCT,包括668例患者。纳入文献中1篇文献质量为A级,8篇文献为B级,1篇文献为C级。系统评价结果显示:采用MEBT/MEBO为主处理创面的疗效优于对照组〔OR=3.94,95%CI(2.30,6.77),P<0.000 01〕,亚组分析亦支持上述结果,且未发现治疗不良反应。结论基于目前的研究,MEBT/MEBO治疗糖尿病足疗效肯定,无不良反应,是临床糖尿病足的有效治疗方法之一。Objective To review systematically the efficacy and safety of moist exposed burn therapy（ MEBT） /moist exposed burn ointment（ MEBO） for diabetic foot ulcer. Methods Medline,EMBase,Cochrane Library,CBM,CNKI,VIP and Wanfang（ WF） database were searched for randomized controlled trials（ RCT） of MEBT /MEBO for diabetic foot ulcers and read some related journals as well. The quality of the enrolled literatures were evaluated and used RevMan 5. 1 software to perform systematic review. Results A total of 10 literatures of RCT including 668 patients. One of the literatures was A- level,8 were B- level,1 was C- level. By systematic review showed that the effect of MEBT /MEBO on wound surface was superior to that of control group〔OR = 3. 94,95% CI（ 2. 30,6. 77）,P 〈0. 000 01〕. And subgroup analysis supported the above results without any adverse reactions. Conclusion MEBT /MEBO,more effective and safer than other treatments for diabetic foot,is one of the effective methods in clinical treatment of diabetic foot.

关 键 词：糖尿病足 皮肤溃疡 系统评价 湿润暴露疗法 湿润烧伤膏 

分 类 号：R587.29[医药卫生—内分泌]