腺苷三磷酸对冠状动脉平滑肌细胞大电导钙离子激活钾通道的作用  

Effects of ATP on BK Channels of Coronary Artery Smooth Muscle Cells

作　　者：王湘芸[1] 钱玲玲[1] 王如兴[1] 李肖蓉[1] 

机构地区：[1]南京医科大学附属无锡市人民医院心内科,江苏无锡214023

出　　处：《医学综述》2014年第23期4231-4234,共4页Medical Recapitulate

基　　金：国家自然科学基金(81070157;81370303);江苏省自然科学基金(BK2011179);江苏省人事厅"六大人才高峰"第七批高层次项目(006);江苏省医学重点人才资助项目(RC201134)

摘　　要：冠状动脉平滑肌细胞膜上存在许多大电导钙离子激活钾通道(BK通道),该通道具有电压依赖性和钙敏感性。研究发现,腺苷三磷酸可通过激活非选择性阳离子门控通道P2X受体使细胞外钙离子内流增加,也可以通过G蛋白偶联受体P2Y使细胞内三磷酸肌醇敏感钙库释放钙离子,升高细胞内钙浓度,从而激活BK通道,起到扩张冠状动脉的作用。Large conductance calcium activated potassium channels are widely distributed in coronary smooth muscle ceils, which have voltage-dependent and calcium-sensitive characteristics. Studies have dem- onstrated that adenosine triphosphate （ATP） increases calcium influx via activation of nonselective cation channel P2XR, and also increases calcium release from IP3-sensitive calcium pool by the activation of G pro- tein couple receptor P2YR, which in turn elevates intracellular calcium concentration, activates large conductance calcium-activated potassium channels and plays a role in coronary dilation.

关 键 词：大电导钙离子激活钾通道 腺苷三磷酸 冠状动脉 

分 类 号：R331.38[医药卫生—人体生理学]