沉默信息调节因子相关酶类1/核因子κB信号通路与2型糖尿病的关系  

Relationship between SIRT1/NF-κB Signal Pathway and Type 2 Diabetes Mellitus

作　　者：乔娜[1] 傅玉才[2] 许文灿[1] 

机构地区：[1]汕头大学医学院第一附属医院内分泌科,广东汕头515041 [2]汕头大学医学院细胞衰老实验室,广东汕头515041

出　　处：《医学综述》2014年第23期4328-4330,共3页Medical Recapitulate

基　　金：国家自然科学基金(81370925);广东省自然科学基金(10151503102000017;S2012010009336;2008B030301369)

摘　　要：2型糖尿病是一种年龄、肥胖及炎症相关性疾病。随着年龄增长以及脂肪组织的积聚,炎性细胞激活以及炎性因子释放导致胰岛素靶细胞敏感性下降,形成胰岛素抵抗,即2型糖尿病前期。沉默信息调节因子相关酶类1(SIRT1)是一种组蛋白脱乙酰化酶,在哺乳动物糖脂能量代谢和生命活动中扮演重要角色;核因子κB可诱导多种炎性细胞因子,是炎性反应和细胞生存的枢纽环节。该文主要讨论SIRT1通过调节核因子κB的表达作用于2型糖尿病的发病,为2型糖尿病的预防以及治疗提供更多理论基础。Type 2 diabetes mellitus is a metabolic disorder relevant to aging, obesity, and inflammation. Due to aging and accumulation of fat tissues,insulin resistance, which is the prophase of type 2 diabetes mellitus results from the sensitivity decrease of insulin target cells caused by the activation of inflammatory cells and release of inflammatory factors. SIRT1 （ silent information regulator related enzymes-1 ） is a histone deacetylase which plays important role in the energy metabolism of glucose and lipid and life span. NF-kappaB can induce various inflammatory cytokines,it is the key point of inflammation and cell survival. Here is to make a review of the relationship between SIRT1/NF-κB signal pathway and type 2 diabetes mellitus, in order to provide theoretical basis for the prevention and treatment for type 2 diabetes mellitus.

关 键 词：沉默信息调节因子相关酶类1 2型糖尿病 代谢 炎症 

分 类 号：R587.1[医药卫生—内分泌]