脑白质疏松轻度认知障碍中医干预模糊综合评价研究  

Analysis based on fuzzy comprehensive evaluation of TCM intervention in treating leukoaraiosis mild cognitive impairment

作　　者：张艳霞[1] 张允岭[1] 金香兰[1] 高芳[1] 郭蓉娟[1] 陈志刚[1] 曹晓岚[2] 陈志强[3] 张玉莲[4] 赵建军[5] 王少杰[6] 侯小兵[7] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]山东中医药大学附属医院,济南250011 [3]河北医科大学中医院,石家庄050011 [4]天津中医药大学第二附属医院,天津300150 [5]长春中医药大学第一附属医院,长春130021 [6]北京大学人民医院,北京100044 [7]中国中医科学院望京医院,北京100102

出　　处：《中华中医药杂志》2014年第12期3708-3711,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2008年中医药行业科研专项(No.200807011);2010年中医药行业科研专项(No.201007002);2010年度北京市社区中医药服务科技示范项目;北京市新医药学科群建设项目(No.XK100270569);北京中医药大学创新团队(No.2011-CXTD-23);2011年北京市科技计划课题(No.2111107056811040)~~

摘　　要：目的:评价中医综合干预治疗脑白质疏松轻度认知障碍(LAMCI)的临床疗效。方法:选取符合纳入标准的LAMCI患者182例,随机分为对照组90例,治疗组92例。对照组给予非干预方案,治疗组给予复方苁蓉益智胶囊口服联合中医特色疗法综合干预6个月,随访3个月,观察其对患者蒙特利尔认知(Mo CA)积分,日常生活能力(ADL)积分、社会功能活动(FAQ)积分及中医证候积分。结果:Mo CA总分比较,两组有显著性差异(P<0.05);两组ADL和FAQ积分差异均无统计学意义;两组核心症状总分比较,差异有统计学意义(P<0.05);上述四方面模糊综合评价疗效显示治疗组优于对照组。结论:LAMCI中医综合干预具有一定临床疗效,值得临床推广,模糊综合评价可为类似研究提供依据和方法。Objective： To evaluate the clinical efficacy of TCM comprehensive treatment protocols in treating the leukoaraiosis mild cognitive impairment （LAMCI）. Methods： One hundred and eighty-two LAMCI patients were selected and randomly divided into a treatment group （92 cases） and a control group （90 cases）. The control group was given no intervention, and the treatment group was given FuFang Congrong Yizhi Capsule and typical TCM therapy for 6 months, and followed up for 3 months. MoCA scores, ADL scores, FAQ scores and TCM syndrome scores were observed. Results： MoCA scores in two groups had a significant difference （P〈0.05）. ADL and FAQ scores in two groups had no statistically significant difference. The core Chinese symptom scores in two groups had a statistically significant difference （P〈0.05）. According to above four aspects, fuzzy synthetic evaluation showed that the treatment group achieved better therapeutic effects than the control group. Conclusion： TCM comprehensive intervention in treating the LAMCI has a certain clinical efficacy which is worth to spread in the clinical, and fuzzy comprehensive evaluation could provide the basis and method for the similar research.

关 键 词：脑白质疏松 较度认知障碍 中医干预方案 模糊综合评价 

分 类 号：R277.7[医药卫生—中医学]