脑心通胶囊对中风病气虚血瘀证治疗前后症状评分与肱动脉内皮功能指标相关性研究  

Correlation research between brachial artery endothelial function and the symptom scores of the stroke patients with syndrome of blood stasis due to deficient qi treated by Naoxintong Capsule

作　　者：陈婧[1] 杨惠民[1] 杨正[2] 李品慧[3] 叶超[1] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学基础医学院,北京100029 [3]北京中医药大学东方医院,北京100078

出　　处：《中华中医药杂志》2014年第12期4036-4039,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学东直门医院课题(No.2012)~~

摘　　要：目的:探讨脑心通胶囊对中风病气虚血瘀证患者肱动脉内皮功能的影响及其与症状评分的相关性。方法:将13例中风病气虚血瘀证患者随机分为治疗组及对照组,治疗组给予常规治疗方案加脑心通胶囊,对照组给予常规治疗方案。分别在治疗开始时和治疗3个月结束后两个时间点进行中医气虚血瘀证候评价量表、NIHSS卒中量表及肱动脉内皮功能的测评,观察两组疗效。结果:治疗组治疗前后症状学评分较前改善(P<0.05)。治疗组治疗前后的肱动脉内皮功能测评结果略有改善但无统计学意义。治疗组治疗前后的中医气虚血瘀证候评分差值与肱动脉内皮功能变化,两者成正相关,但无显著相关性;NIHSS评分差值与肱动脉内皮功能变化,两者成正相关,但无显著相关性。结论:应用脑心通胶囊治疗中风病气虚血瘀证患者,能够对于中风病气虚血瘀证患者血管内皮细胞功能障碍的病理本质进行治疗,值得进一步推广。Objective： To observe the effect of Naoxintong Capsule on the brachial artery endothelial function and the correlation between brachial artery endothelial function and the symptom scores of the stroke patients with syndrome of blood stasis due to deficient qi. Methods： Thirteen stroke patients with syndrome of blood stasis due to deficient qi were randomly divided into control group and treatment group. Apart from the conventional treatment, the patients in control group were treated with Naoxintong Capsule additionally. The TCM symptoms score of the two groups, the U.S. National Institutes of Health Stroke Scale （NIHSS） score, and the brachial artery were observed at the beginning and after 3 months of treatment. Results： TCM Symptomatology score of treatment group was improved with statistically significance （P〈0.05） over the pre-treatment score. The brachial artery endothelial function of treatment group was improved slightly but not significant. Correlation study between score of the TCM Symptomatology and brachial artery endothelial function before and after the treatment indicated a positive correlation but no significant. The NIHSS scores and brachial artery endothelial function of treatment group before and after the treatment indicated a positive correlation but no significant correlation. Conclusion： Naoxintong Capsule could improve the clinical symptoms of the stroke patients with the syndrome of blood stasis due to deficient qi. It also could ameliorate the artery endothelial function damage and treat the pathological nature of stroke patients with syndrome of blood stasis due to deficient qi and worthy of further promotion.

关 键 词：肱动脉内皮功能 相关性分析 中风病 气虚血瘀证 脑心通胶囊 

分 类 号：R277.7[医药卫生—中医学]