短链脂肪酸受体GPR43的研究进展  

Advances in Short-chain Fatty Acid Receptor GPR43

作　　者：刘鸿飞[1] 魏云林[1] 卢磊磊[2] 季秀玲[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,中国云南昆明650500 [2]江苏大学生命科学研究院,中国江苏镇江212013

出　　处：《生命科学研究》2014年第6期557-564,共8页Life Science Research

基　　金：云南省后备人才基金项目(2009CI027)

摘　　要：短链脂肪酸受体(G protein-coupled receptor 43,GPR43)属于G蛋白偶联受体(G protein-coupled receptors,GPCR)家族,因其与脂肪和糖代谢相关,在过去的10年中其研究日益受到重视。研究表明,GPR43不仅可以通过参与调节食欲和胃肠肽的分泌来调节脂肪的分解与形成,最终与代谢性疾病如肥胖、2型糖尿病和心血管病的密切相关;而且GPR43还参与调节人身体血脂浓度和炎症发生过程,甚至还与细胞的癌变密切相关。GPR43作为糖代谢、脂肪代谢的重要调节受体,已经成为一个重要的药物筛选靶点。针对GPR43受体的研究现状进行了总结并对今后的应用研究进行了展望。The short-chain fatty acid receptor G protein-coupled receptor 43 （GPR43） belongs to G-pro- tein-coupled receptor （GPCR） family. It has been found to be associated with obesity and glucose/lipid metabolism, for which has drawn a huge attention in the past decade. Recent studies have shown that GPR43 mediate lipolysis and adipogenesis through the regulation of appetite and secretion of gastrointestinal peptide, and it is closely related to the incidence of metabolic diseases such as obesity, type 1] diabetes mellitus and cardiovascular disease. GPR43 has effects on regulating the concentration of human blood lipid and inflammation processes, even cellular cancerization as well. As an important modulator of glucose and lipid metabolism, GPR43 has become an important target for drug screening. The research status and the trend on applied study of GPR43 are reviewed.

关 键 词：短链脂肪酸 G蛋白偶联受体(GPCR) 短链脂肪酸受体(GPR43) 

分 类 号：Q955[生物学—动物学]