非甾体类抗炎药联合α1受体阻滞剂治疗输尿管结石的临床效果  

Clinical efficacy of non-steroidal anti-inflammatory drugs and α1-adrenergic antagonist on the patients with ureteral stones

作　　者：秦杨[1] 徐贤华[1] 李改丽[1] 李烨瑾 潘泉蓉 徐静[1] 范丽娟[1] 

机构地区：[1]成都军区总医院综合内科,610083

出　　处：《中国综合临床》2014年第12期1284-1286,共3页Clinical Medicine of China

摘　　要：目的 观察非甾体类抗炎药联合α1肾上腺素能受体阻滞剂在输尿管结石伴绞痛治疗中的临床效果.方法 将128例输尿管结石伴绞痛患者应用随机数字表分为两组,每组64例,均给予坦索罗辛0.4 mg口服,生理盐水1 000 ml静脉滴注;治疗组给予酮咯酸氨丁三醇注射液10 mg肌内注射,对照组给予盐酸哌替啶10 mg肌内注射;留院观察6～8h复查超声观察结石排出情况,仍未排出者行体外震波碎石术及其他治疗.结果 治疗组止痛有效率为96.9％ （62/64）,对照组为100％ （64/64）,两组止痛有效率差异无统计学意义（x^2 =2.03,P=0.50）;治疗组自行排石率为28.1％ （18/64）,高于对照组的12.5％ （8/64）,差异有统计学意义（x^2=4.83,P=0.05）.结论 非甾体类抗炎药能有效缓解输尿管结石引起的绞痛,其总有效率同哌替啶相当,联合α1受体阻滞剂促进排石的作用优于哌替啶.Objective To investigate the clinical effect of non-steroidal anti-inflammatory drugs and αl-adrenergic antagonist on treating patients with ureteral stones.Methods A total of 128 patients with ureteral colic due to ureteral stones were randomly divided into control and treatment group,and 64 cases in each group.Both two groups were treated with tamsulosin 0.4 mg oral,intravenous injection of saline 1000 mL Patients in treatment group were received intramuscular non-steroidal anti-inflammatory drugs（10 mg） and patients in control group were received pethidine hydrochloride（10 mg）.Ultrasound exam were performed after 6-8 h to evaluate the stone expulsive rate.Extracorporeal shock wave lithotripsy and other treatment were underwent when the stone was still not discharge.Results The effective rate of analgesia was 96.9% （62/64） in treatment group and 100% （64/64） in control group（x^2 =2.03,P =0.50）.The stone expulsion rate in treatment group was 28.1% （18/64）,higher than that in control group（12.5% （8/64）,x^2 =4.83,P =0.05）.Conclusion It is effective to relive ureteral cohc with non-steroidal anti-inflammatory drugs only,and it is better than pethidine in promote stone expulsion when they both used with α1-adrenergic antagonist.

关 键 词：输尿管结石 非甾体类抗炎药 Α1肾上腺素能受体阻滞剂 盐酸哌替啶 

分 类 号：R693.4[医药卫生—泌尿科学]