健脾增敏汤对2型糖尿病胰岛素抵抗的影响  

Effect of Jianpi Zengmin Decoction on Insulin Resistance in Type 2 Diabetes Mellitus

作　　者：叶仁群[1] 黄寅銮[1] 彭俊杰[1] 宋银枝[1] 宋群利[1] 谢嘉嘉[1] 

机构地区：[1]深圳市宝安区中医院,广东深圳518133

出　　处：《中医学报》2014年第11期1565-1567,共3页Acta Chinese Medicine

基　　金：深圳市科技计划项目(编号:201203271);深圳市宝安区科技计划项目(编号:2012043)

摘　　要：目的:观察健脾增敏汤对2型糖尿病患者胰岛素抵抗的影响。方法:将既符合2型糖尿病胰岛素抵抗诊断标准、又符合"脾虚湿盛、浊瘀内阻证"辨证分型标准患者100例,随机平均分为治疗组和对照组。治疗组在基础治疗的同时加服健脾增敏汤,对照组在基础治疗的同时加服盐酸二甲双胍,均治疗8周。比较两组治疗前后临床症状、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、血脂、空腹血糖(FPG)、餐后2小时血糖(2 hPG)的变化。结果:治疗组有效率为90%,对照组为74%,两组有效率比较,差异有统计学意义(P<0.05)。与治疗前比较,两组患者HOMA-IR、BMI、TG、CHOL、FBG、2hPG水平均明显下降(P<0.05);其中治疗组治疗后HOMA-IR和TG水平与对照组治疗后比较,差异有统计学意义(P<0.05)。结论:健脾增敏汤能有效改善2型糖尿病患者的胰岛素抵抗。Objective：To observe the effect of Jianpi Zengmin decoction on insulin resistance in type 2 diabetes. Methods：100 patients conformed to western medicine diagnosis of type 2 diabetes and traditional Chinese medicine＆#39;s Spleen wet Sheng,turbidity and blood stasis resistance were randomly divided into treatment group and control group,50 cases in each group. Patients were treated with basic treatment plus Jianpi Zengmin decoction in treatment group,and basic treatment plus oral metformin hydrochloride in control group. Af-ter treatment for 8 weeks,comparative analysis of clinical symptoms,insulin resistance indexes（ HOMA-IR）,body mass index（ BMI）, blood fat,fasting blood-glucose（FPG）and 2 hour postprandial blood glucose（2hPG）. Results：The total effective rate was 90% and 74% respectively in treatment group and control group,the difference was significant（P〈0. 05）. HOMA-IR,BMI,TG,CHOL,FBG, 2hPG in both groups were reduced significantly（P〈0. 05）. Compared the HOMA-IR and TG levels of treatment group and control group after treatment,the difference was statistically significant（P〈0. 05）. Conclusion：Jianpi Zengmin decoction could effectively im-prove insulin resistance in type 2 diabetes.

关 键 词：健脾增敏汤 2型糖尿病 胰岛素抵抗 

分 类 号：R259.871[医药卫生—中西医结合]