万寿菊叶黄素的长期毒性研究  

Study on Chronic Toxicity of Marigold Lutein

作　　者：翟建英[1] 陈会丛[1] 张广平[1] 杨海润[1] 张思玉[1] 朱晓光[1] 蒋威[1] 解素花 

机构地区：[1]北京中研同仁堂医药研发有限公司,中药复方新药开发国家工程研究中心,北京100079 [2]北京同仁堂科技发展股份有限公司,北京100079

出　　处：《中医学报》2014年第11期1608-1615,共8页Acta Chinese Medicine

基　　金：国家高技术研究发展计划(863计划)基金资助项目(编号:2010AA023006)

摘　　要：目的:观察万寿菊叶黄素的长期毒性,为其安全应用提供参考。方法:将大鼠随机分为5组,空白对照组,溶媒对照组,叶黄素高剂量组[57.0 mg·(kg·d)-1]、中剂量组[23.5 mg·(kg·d)-1]、低剂量组[5.7 mg·(kg·d)-1],连续给药26周,停药4周,观察大鼠的一般行为、体质量增长、食量消耗、血液学及血液生化学指征、尿常规检查、系统尸解及组织病理学诊断。结果:长期毒性实验中,与同期溶媒对照组比较,叶黄素高剂量组、中剂量组、低剂量组动物行为活动、进食量等检查均未见异常;血液学指标、血液生化指标和尿液指标未发现与供试品有关的异常改变,病理组织学检查未发现与叶黄素相关的异常改变。结论:在本实验条件下,未观察到万寿菊叶黄素明显毒性反应,应用较安全。Objective：To study the chronic toxicity of Marigold Lutein in rats. Methods：Rats were randomly divided into control group,vehi-cle control group,high dose group（57. 0 mg·kg-1 ）,middle dose group（23. 5 mg·kg-1 ）and low dose group（5. 7 mg·kg-1 ）. Rats were given gavage for consecutive 26 weeks,and 4 weeks rest. The general conditions were observed and the related indexes were detec-ted,such as body weight,food consumption,blood,blood biochemistry,urine routine examination,autopsy and histopathologic diagnosis. Results：Compared with vehicle control group,no significant differences were observed in rat＆#39;s behaviors,food intake and relative exami-nation indexes,such as routine control of blood,blood biochemistry,urinalysis and organ coefficient. Conclusion：Marigold lutein is safe and has no side-effects in rats.

关 键 词：万寿菊叶黄素 长期毒性 大鼠 

分 类 号：R285.5[医药卫生—中药学]