静脉应用唑来膦酸注射液的临床安全性  

Safety on intravenous use of zoledronic acid injection

作　　者：赵淑慧 

机构地区：[1]北京顺义区中医医院药剂科,北京101300

出　　处：《实用药物与临床》2014年第12期1601-1603,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的分析唑来膦酸注射液应用的安全性。方法采用回顾性研究方法,对我院2010年1月至2014年1月使用唑来膦酸注射液的710例患者的药物不良反应进行统计分析。结果唑来膦酸注射液的不良反应以发热最常见,发生率为95.07%,其次是低血钙、低血磷。全部不良反应均为一过性反应,无严重不良反应发生。结论唑来膦酸的不良反应发生率高,应积极给予退热治疗,并及时给予血钙、磷、钾、镁、铁、肌酐及血常规监测,以确保不良反应的平稳过渡。Objective To analyze the safety of zoledronic acid injection in 710 patients.Methods The adverse reactions of patients who used zoledronic acid injection in our hospital from January 2010 to January 2014 were retrospectively analyzed.Results Fever was the most common adverse reaction of zoledronic acid injection,the incidence rate was 95.07％,followed by hypocalcemia,hypophosphatemia.All the adverse effects were transient response,no serious adverse reactions occurred.Conclusion The rate of adverse drug reaction of zoledronic acid was high,the antipyretic therapy should be given,and calcium,phosphorus,potassium,magnesium,iron,creatinine,blood routine monitoring should also be monitored in patients using zoledronic acid.

关 键 词：唑来膦酸注射液 不良反应 发热 

分 类 号：R96[医药卫生—药理学]