甲巯咪唑的严重不良反应及处理对策  

Serious adverse drug reactions and processing measures of thiamazole

作　　者：王晓虹[1] 马建丽[1] 罗艳[1] 黄欣欣[1] 刘京伟[1] 

机构地区：[1]解放军总医院第一附属医院药剂药理科,北京100048

出　　处：《实用药物与临床》2014年第12期1604-1606,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨并分析甲巯咪唑严重不良反应(ADR)发生的类型及处理对策,为临床安全、合理使用甲巯咪唑提供参考。方法检索国内外有关甲巯咪唑不良反应的病例报道,对其严重不良反应发生类型及处理对策进行分析和总结。结果甲巯咪唑的严重不良反应以血液系统损害及肝损害最为多见,另外可见皮肤损害、骨骼肌肉损害及内分泌异常等。结论临床医药人员应重视甲巯咪唑引起的严重不良反应及处理对策,加强临床用药监测,防止和减少ADR的发生率,保证用药安全。Objective To investigate the types and processing measures of serious adverse drug reactions of thiamazole,in order to provide useful references for safe and rational drug use in clinic.Methods The types of serious adverse drug reactions and processing measures were summarized and analyzed by retrieving the domestic and foreign reported cases of adverse reactions of thiamazole.Results Of all ADR cases,hematological disorders and liver damages took up the biggest proportion.Besides,the adverse drug reactions included skin damage,skeletal and musle injury,endocrine abnormality and so on.Conclusion The clinical medical personnel should pay attention to adverse drug reactions induced by thiamazole and have an intimate knowledge of the processing measures,strengthen observation of patients during medication in order to prevent and reduce the serious ADR and to ensure the safety of drug use.

关 键 词：甲巯咪唑 严重不良反应 处理对策 

分 类 号：R977[医药卫生—药品]