高龄妊娠期高血压疾病患者血浆总同型半胱氨酸水平与叶酸和维生素B_(12)的关系研究  

Plasma total homocysteine and its relationship with folic acid and vitamin B_(12) in elder pregnant women with gestational hypertension

作　　者：陆玉良[1] 程震锋[1] 韦凡平[1] 邱升强[1] 

机构地区：[1]湖州市中心医院心内科,313000

出　　处：《浙江医学》2014年第21期1782-1783,1790,共3页Zhejiang Medical Journal

摘　　要：目的探讨高龄妊娠期高血压疾病患者血浆总同型半胱氨酸(tHcy)、血清叶酸和Vit B_(12)水平3者的关系及其临床意义。方法选择67例高龄妊娠期高血压疾病患者(A组)、96例同期非高龄妊娠期高血压疾病患者(B组)、73例同期高龄妊娠妇女(C组)和152例同期非高龄妊娠妇女(D组),用荧光偏振免疫分析法测定血浆tHcy水平,离子捕捉免疫分析法测定血清叶酸水平,微粒子酶联免疫分析法测定血清Vit B_(12)水平,进行分析和比较。结果 A组血浆tHcy水平、血清叶酸和Vit B_(12)水平分别为(18.05±6.1 1)μmol/L、(8 34±3.54)nmol/L和(304.23±75.38)pmol/L,B组分别为(1 1 18±3 54)μmol/L、(12.36±4.53)nmol/L和(364 23±89.35)pmol/L,C组分别为(8.21±3.76)μmol/L、(15.54±5 23)nmol/L和(404.53±92.35)pmol/L,D组分别为(7.81±3.23)μmol/L、(16.34±5.67)nmol/L和(421.73±1 13.55)pmol/L。A组tHcy水平高于其他3组(均P<0.01),叶酸和Vit B_(12)水平则低于其他3组(均P<0.01),B组tHcy水平高于C组和D组(均P<0.01),叶酸和Vit B_(12)水平则低于C组和D组(均P<0.01)。相关性分析显示,A、B两组血浆tHcy水平与血清叶酸、Vit B_(12)水平均呈负相关性(r=-0.6372、-0.5747,均P<0.01),而在A组中表现更加明显,其血浆tHcy水平与血清叶酸、Vit B_(12)水平呈高度负相关(r=-0.7653、-0.6843,均P<0.01)。结论妊娠期高血压疾病患者血浆tHcy浓度显著上升,血清叶酸、Vit B_(12)浓度显著下降,随着怀孕年龄的增加这种负相关更加明显。Objective To determine plasma total homocysteine （tHcy） and its relationship with folic acid and vitamin B12 in elder pregnant women with gestational hypertension. Methods Plasma tHcy, serum folic acid and vit B12 level were determined by fluorescence polarization immunoassay （FPIA）, ion capture immunoassay （ICIA） and microparticle enzyme immunoassay （MEIA） in 67 elder patients with gestational hypertension （group A）, 96 normal age patients with gestational hypertension（group B）, 73 normal elder pregnant women （group C） and 152 normal age pregnant women（group D）, respectively. Results The mean plasma tHcy levels were（18.05±6.11）, （11.18±3.54）, （8.21±3.76） and （7.81±3.23）μmol/L in groups A, B, C and D, respective-ly. The serum folic acid levels were （8.34±3.54）, （12.36±4.53）, （15.54±5.23） and （16.34±5.67）nmol/L in groups A. B, C and D, respectively. The mean serum VitB12 levels were （304.23±75.38）, （364.23±89.35）, （404.53±92.35） and （421.73±113.55）pmol/L in groups A, B, C and D, respectively. The level of plasma tHcy in group A was the highest in the four groups （P〈0.01）, but the levels of serum folic acid and vitB12 in group A were the lowest in four groups（P〈0.01）. The levels of plasma tHcy in group B were higher, but serum folic acid and vitB12 levels were lower than those in group C and group D （both P〈0.01）. Correlation analysis showed that plasma tHcy was negatively correlated with serum folic acid and vitB12 in groups A and B （r=- 0.6372、- 0.5747, P〈0.01）;and it was more significantly in group A（r=- 0.7653、- 0.6843, P〈0.01）. Conclusion The levels of plasma tHcy in elder pa-tients with gestational hypertension are significantly increased, while the levels of serum folic acid and vitB12 are significantly de-creased. The negative correlation is more significantly showed with the growing age of pregnancy.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R714.246[医药卫生—妇产科学]