腹壁切口子宫内膜异位症患者病灶组织中Ki67和血清CA125的测定及意义  

Ki67 expression in women with abdominal incisional endometriosis

作　　者：朱红丽[1] 仝进毅[1] 

机构地区：[1]杭州市第一人民医院妇产科,310006

出　　处：《浙江医学》2014年第22期1867-1869,共3页Zhejiang Medical Journal

摘　　要：目的检测腹壁切口子宫内膜异位症患者病灶组织中Ki67的表达和血清CA125水平,探讨其临床意义。方法收集住院手术经病理检查证实为腹壁切口子宫内膜异位症患者38例(研究组),盆腔子宫内膜异位症患者57例(对照组),用免疫组化方法测定两组患者病灶组织中Ki67的表达,放射免疫法测定血清CA125水平,分析其临床资料并进行随访。结果研究组患者Ki67阳性率(52.6%)显著高于对照组(24.6%)(P<0.05),两组Ki67阳性患者的血清CA125水平均显著高于阴性患者(均P<0.05)。研究组无复发病例,而对照组复发率为21.4%(P<0.05)。结论腹壁切口子宫内膜异位症的发病机制可能与盆腔子宫内膜异位症不同;子宫内膜异位症患者Ki67的表达与CA125水平存在一定的正相关。Objective To investigate Ki67 expression in abdominal incisional endometriosis and its significance. Methods Patients with endometriosis （EMS） admitted in Hangzhou First People＇s Hospital from January 2010 to December 2013 were en-rol ed in the study, including 57 cases with pelvic endometriosis and 38 cases with abdominal incisional endometriosis. The ex-pression of proliferating cel nuclear antigen （Ki67） in tissue was detected with immunohistochemical method and serum CA- 125 levels were measured with radioimmunoassay. Results Ki67 expression in abdominal wal endometriosis was significantly high-er than that in pelvic endometriosis （P〈0.05）. Serum CA125 levels in abdominal wal endometriosis was significantly lower than that in pelvic endometriosis （P〈0.05）. Serum CA125 was significantly different between groups of different Ki67 expression （P〈0.05）. Cumulative recurrence rate in abdominal wal endometriosis was significantly lower than that in pelvic endometriosis. CA125 level was higher in EMS with positive Ki67 expression than that in EMS with negative Ki67 expression. Conclusion Ki67 is differently expressed in abdominal incision and in pelvic endometriosis, suggesting that the pathogenesis of abdominal incision endometriosis and pelvic endometriosis may be different;and Ki67 expression may be related to relapse of pelvic endometriosis.

关 键 词：KI67 CA125 腹壁切口 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]