老年缺血性脑卒中患者颈动脉斑块性质与血脂、细胞纤维结合蛋白和同型半胱氨酸水平的关系  

Relationship between carotid artery plaque and lipids,cellular fibronectin,homocysteine level in elderly patients with ischemic stroke

作　　者：周荣佼[1] 王金燕[2] 孙健[3] 

机构地区：[1]滨州医学院附属医院检验科,滨州256603 [2]滨州医学院附属医院疼痛康复二病区,滨州256603 [3]滨州医学院附属医院超声医学科,滨州256603

出　　处：《郑州大学学报（医学版）》2014年第6期876-878,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨老年缺血性脑卒中患者颈动脉斑块性质与血脂、细胞纤维结合蛋白以及同型半胱氨酸水平的关系。方法:选取100例颈动脉斑块伴缺血性脑卒中老年患者为研究组,并且选取同期健康体检的100例对象为对照组,测定2组血脂、血细胞纤维结合蛋白和同型半胱氨酸水平。结果:研究组的胆固醇、低密度脂蛋白胆固醇、细胞纤维结合蛋白及同型半胱氨酸含量均高于对照组(t=6.936、13.260、13.585和13.347,P均<0.001)。易损斑块患者的胆固醇、低密度脂蛋白胆固醇、细胞纤维结合蛋白及同型半胱氨酸含量较稳定斑块患者均升高(t=6.204、3.112、7.438和6.961,P均<0.05)。结论:细胞纤维结合蛋白、同型半胱氨酸水平升高和血脂异常在老年缺血性脑卒中的发生中具有一定的作用,且不同性质颈动脉斑块可能与该病的发生发展有关。Aim：To investigate the relationship between carotid artery plaque and blood lipids , homocysteine （ Hcy） level, cellular fibronectin（c-Fn） in elderly patients with ischemic stroke.Methods：A total of 100 elderly patients with is-chemic stroke and arotid plaques were selected as the study group , and 100 cases of healthy subjects were used as the con-trol group.The lipid, c-Fn and Hcy levels were measured .Results： The TC, LDL-C, c-Fn, and Hcy levels in study group were significantly higher than that in control group （t=6.936, 13.260, 13.585, 13.347,P〈0.001）.The TC, LDL-C, c-Fn, and Hcy levels in vulnerable plaque group were significantly higher than stabilize plaque group （ t=6 .204 , 3.112, 7.438, 6.961,P〈0.05）.Conclusion： In elderly patients with carotid plaques and ischemic stroke , lipids, c-Fn, and Hcy are different from ordinary people .

关 键 词：老年人 缺血性脑卒中 颈动脉斑块 血脂 细胞纤维结合蛋白 同型半胱氨酸 

分 类 号：R446.1[医药卫生—诊断学]