越西木香化学成分的研究  

Study on the chemical constituents from Vladimiria denticulata

作　　者：周金云[1] 宁冰梅[1] 高永莉[1] 方起程[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中国药学杂志》2002年第8期574-577,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金重点项目 ( 2 96 32 0 50 )

摘　　要：目的　对越西木香 (VladimiriadenticulataLing)根化学成分进行研究。方法　用硅胶色谱技术对化合物进行分离 ,并用光谱方法进行结构鉴定。结果　分离鉴定了 9个成分 :β谷甾醇 (β sitosterol,Ⅰ ) ,heptadeca 1 ene 1 1 ,1 3 diyne 8,9,1 0 triol(Ⅱ ) ,乌发醇 (uvaol,Ⅲ ) ,熊果酸 (ursolicacid ,Ⅳ ) ,1 羟基 2 ,3 ,5 三甲氧基 酮 (1 hydroxy 2 ,3 ,5 trimethoxyxanthone ,Ⅴ ) ,1 羟基 2 ,3 ,4,7 四甲氧基 酮 (1 dihydroxy 2 ,3 ,4,7 tetramethoxyxanthone,Ⅵ ) ,1 羟基 2 ,3 ,4,5 四甲氧基 酮 (1 hydroxy 2 ,3 ,4,5 tetramethoxyxanthone ,Ⅶ ) ,1 ,7 二羟基 3 ,4 二甲氧基 酮 (1 ,7 dihydroxy 2 ,4 dimethoxyxanthone ,Ⅷ ) ,菜蓟苦素 (cy naropicrin ,Ⅸ )。 结论　OBJECTIVE: To investigate the chemical constituents in the roots of Vladimiria denticulata Ling. METHODS: The ingredients were isolated by the silica gel chromatographic technology, and their structures were identified by the spectral methods including UV, IR, MS, 1H-NMR and 13C-NMR respectively. RESULTS: Nine ingredients were isolated and identified as β-sitosterol (I), heptadeca-1-ene-11, 13-diyne-8, 9, 10-triol (II), uvaol (III), ursolic acid (IV), 1-hydroxy-2, 3, 5-trimethoxyxanthone (V), 1-hydroxy-2, 3, 4, 7-tetrathoxyxanthone (VI), 1-hydroxy-2, 3, 4, 5-tetrathoxyxanthone (VII), 1, 7-dihydroxy-3, 4-dithoxyxanthone (VIII) and cynaropicrin (IX). CONCLUSION: All the ingredients were isolated from this plant for the first time.

关 键 词：越西木香 Sa酮 五环三萜 硅胶色谱技术 化学成份 

分 类 号：R284.1[医药卫生—中药学]