肺结核合并糖尿病患者血清IL-2、TNF-α的表达及临床意义  

Expression and clinical significance of serum IL-2 and TNF-αin patients with pulmonary tuberculosis combine diabetes

作　　者：冉燕[1] 罗亚文[2] 史军丽[3] 赵建军[1] 周凛梅 

机构地区：[1]遵义医学院附属医院呼吸二科,贵州遵义563000 [2]遵义医学院附属医院感染科,贵州遵义563000 [3]遵义医学院附属医院影像科,贵州遵义563000

出　　处：《重庆医学》2014年第34期4589-4590,4593,共3页Chongqing medicine

基　　金：贵州省遵义医学院附属医院硕士启动基金[院字2009(10)号]

摘　　要：目的观察肺结核合并糖尿病患者血清IL-2、TNF-α的表达,并初步探讨其临床意义。方法试验分为对照组(门诊健康体检者,n=10)、肺结核组(n=20)、糖尿病组(n=20)和肺结核合并糖尿病组(n=20),治疗2个月后根据病情转归将肺结核合并糖尿病组分为好转组及恶化组,ELISA法检测血清中IL-2、TNF-α水平。结果治疗前:肺结核组、糖尿病组、肺结核合并糖尿病组血清IL-2水平均降低(P<0.05),其中肺结核合并糖尿病组低于肺结核组和糖尿病组(P<0.05);肺结核合并糖尿病组、肺结核组、糖尿病组血清TNF-α水平均升高(P<0.05),其中肺结核合并糖尿病组高于糖尿病组(P<0.05);治疗后:肺结核合并糖尿病好转组血清IL-2水平上升,而TNF-α水平有明显下降(P<0.05),恶化组治疗前后变化不明显(P>0.05)。结论IL-2、TNF-α在肺结核合并糖尿病的免疫发病机制中起着一定的作用,其动态变化能反应肺结核合并糖尿病的病情发展及转归。Objective To investigate the expression of serum interleukin-2（IL-2）,tumor necrosis factor-α（TNF-α）in the pa-tients with pulmonary tuberculosis and diabetes,and prelininary explore its clinical significance.Methods Experiment were divided into control group（health check-up outpatient,n=10）,pulmonary tuberculosis group（n=20）,diabetes group（n=20）,tuberculosis combine diabetes group（n=20）,tuberculosis combine diabetes group was divided into improved group,diabetes group and deterio-rated group after 2 months with therapy according to disease outcome,ELISA assay was used to measured the level of serum IL-2 and TNF-α.Results Before treatment：serum IL-2 levels of pulmonary tuberculosis group,diabetes group and pulmonary tuberculo-sis combine diabetes group were reduced （P〈0.05）,and the pulmonary tuberculosis group was lower than the pulmonary tubercu-losis group and diabetes group （P〈0.05）;serum TNF-αlevels of pulmonary tuberculosis combine diabetes group,pulmonary tu-berculosis group and diabetes group increased （P〈0.05）,and that of pulmonary tuberculosis combine diabetes group was higher than that of diabetes group （P〈0.05）.After treatment：the level of serum IL-2 increased and TNF-αsignificantly decreased in pul-monary tuberculosis combine diabetes improved group （P〈0.05）,the deterioration group had no change（P〉0.05）.Conclusion IL-2 and TNF-αplay a role in the immune pathogenesis of tuberculosis combine diabetes,which dynamic changes can reflect the progression and outcome of pulmonary tuberculosis combine diabetes.

关 键 词：结核 肺 糖尿病 白细胞介素2 

分 类 号：R521[医药卫生—内科学] R587.1[医药卫生—临床医学]