母体血清C反应蛋白诊断早发性新生儿败血症的临床价值  

Clinical value of maternal C-reactive protein in predicting early-onset neonatal sepsis

作　　者：刘文君[1] 丁国芳[1] 刘红[1] 

机构地区：[1]首都医科大学附属北京儿童医院新生儿中心NICU,北京100045

出　　处：《重庆医学》2014年第34期4605-4607,共3页Chongqing medicine

摘　　要：目的探讨母体血清C反应蛋白在诊断早发性新生儿败血症（EONS）中的作用。方法以该院2010年1月至2013年6月收治的65例早产新生儿（妊娠28-36周）及其母亲为研究对象,新生儿分成败血症组（n=28）和对照组（n=37）。免疫比浊法测定产妇分娩72h内血清C反应蛋白的水平,建立C反应蛋白水平ROC曲线,将母亲分为C反应蛋白阳性组（≥1.35mg/dL,n=25）和C反应蛋白阴性组（〈1.35mg/dL,n=40）,比较母体血清C反应蛋白水平与早发性新生儿败血症的关系。结果新生儿败血症组母体血清C反应蛋白水平显著高于对照组[（3.61±2.85）mg/dL vs.（0.82±0.73）mg/dL,P〈0.01]。母体血清C反应蛋白预测新生儿败血症灵敏度和特异度分别为72.0%和83.0%,母体血清C反应蛋白阳性组新生儿败血症发病率明显高于C反应蛋白阴性组（71.4%vs.28.6%,P〈0.01）,其新生儿患败血症的危险系数是母体C反应蛋白阴性组的10.54倍（P〈0.01）。结论母体血清C反应蛋白升高与早发性新生儿败血症显著相关,母体血清C反应蛋白可作为早期诊断早发性新生儿败血症的指标。Objective To evaluate the diagnostic performance of C reactive protein（CRP）in predicting early onset neonatal sep-sis.Methods Those in the study were 65 preterm singleton neonates（gestational age at delivery was 28-36 weeks）and their moth-ers in the hospital from January 2010 to June 2013 and the neonate were divided into sepsis group（n=28）and controls（n=37）.Im-munoturbidimetry was adopted to detect the CRP measurement within 72 h after delivered,the ROC curve of maternal CRP was used,mothers were divided into CRP positive group（CRP≥1.35 mg/dL,n=25）and CRP negative group（CRP〈1.35 mg/dL,n=78）,comparing the relationship between maternal serum CRP level and early-onset neonatal sepsis.Results Maternal CRP was sig-nificantly higher in neonatal sepsis group than that in control group[（3.61±2.85）mg/dL vs.（0.82±0.73）mg/dL,P〈0.01].The sensitivity,specificity of maternal serum CRP level were 72.0% and 83.0% for predicting neonatal sepsis.Incidence of neonatal sepsis in maternal CRP positive group was significantly higher than that of maternal CRP negative group（71.4% vs.28.6%,P〈0.01）and the relative risk of neonatal sepsis was 10.54 times that of the maternal CRP negative group（P〈0.01）.Conclusion The elevated levels of maternal serum CRP were significantly associated with early onset neonatal sepsis.Maternal CRP could be used for early diagnosis of early-onset neonatal sepsis.

关 键 词：C反应蛋白质 早产 胎膜早破 早发性新生儿败血症 绒毛膜炎 

分 类 号：R722.134[医药卫生—儿科]