体外授精-胚胎移植后早期自然流产相关因素分析  

Analysis of the related factors for early spontaneous abortion after in vitro fertilization and embryo transfer

作　　者：符免艾 李娟 冼梅兰 张云霞[3] 

机构地区：[1]海南省农垦总医院生殖科,海南海口571100 [2]海南医学院,海南海口571199 [3]海南医学院生物化学教研室,海南海口571100

出　　处：《海南医学》2014年第24期3637-3639,共3页Hainan Medical Journal

基　　金：海南省卫生厅科研项目(编号:琼卫2013自筹-20)

摘　　要：目的探讨辅助生殖技术(ART)治疗后流产的发生率及其相关因素。方法回顾性分析2009年1月至2012年6月在本中心行体外授精-胚胎移植(IVF-ET)治疗后妊娠的166例孕妇的临床资料,根据是否自然流产分为流产组(n=35)和对照组(n=131),比较两组患者年龄、不孕年限、基础内分泌、促性腺激素使用天数(Gn天数),促性腺激素使用总量(Gn总量)、获卵个数、受精方式、内膜厚度等的差异,分析可能影响妊娠结局的因素。结果流产组患者年龄较对照组高,促排卵药物(Gn)使用总量多于对照组,基础FSH水平高于对照组,获卵数低于对照组,上述指标比较差异均有统计学意义(P<0.05),两组的不孕年限、内膜厚度比较差异均无统计学意义(P>0.05),单精子卵胞浆内显微注射(ICSI)组中流产率低于IVF组流产率,差异有统计学意义(P<0.05)。结论引起IVF-ET早期妊娠丢失的原因复杂,可能与患者年龄、基础FSH水平、Gn总量等因素相关。Objective To discuss the incidence of early spontaneous abortion and its related factors after as-sisted reproductive technology （ART）. Methods The clinical data of 166 pregnant women undergoing in vitro fertil-ization and embryo transfer （IVF-ET） from January 2009 to June 2012 in our department were retrospectively ana-lyzed, which were divided into spontaneous abortion group （n=35, women suffered early spontaneous abortion） and the control group （n=131, women with successfully pregnancy）. Difference of the age, infertility time, basic endo-crine, days of using Gonadoropin （Gn Days）, the total amount of Gonadotropin （total amount of Gn）, the number of re-trieved oocytes, fertilization method, the intimal thickness were compared between the two groups. The related factors affecting the pregnancy outcome were analyzed. Results Compared with the control group, the average age of the pa-tients in spontaneous abortion group were significantly higher, the total amount of Gn significantly more, the level of FSH was significantly higher, the number of retrieved oocyte was significantly less, all with statistically significant dif-ference （P〈0.05）. The infertility time and the endometrium thickness showed no statistically significant difference be-tween the two groups （P〉0.05）. The abortion frequency treated by intacytoplamicsperm injection （ICSI） were signifi-cantly lower than that treated by IVF （P〈0.05）. Conclusion The factors that effect early abortion after IVF-ET are complex, which might include age, basic FSH level, and the total amount of Gn.

关 键 词：体外受精-胚胎移植 流产 相关因素 

分 类 号：R714.21[医药卫生—妇产科学]