马兜铃酸Ⅰ致癌作用及其与代谢酶关系的研究进展  

Progress in Aristolochic Acid Carcinogenesis and Its Related Metabolic Enzymes

作　　者：杨召聪[1] 陆茵[1] 顾亚琴[1] 汪思亮[1] 刘兆国[1] 张良[1] 

机构地区：[1]南京中医药大学药学院,江苏省药效与安全性评价重点实验室,江苏南京210023

出　　处：《中药新药与临床药理》2014年第6期765-769,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：江苏省科技厅自然科学基金面上项目(BK2012852);江苏省高校优势学科建设工程资助项目(2011XYZ4-003);国家自然科学青年基金(30701106)

摘　　要：马兜铃酸(aristolochic acid,AA)广泛存在于马兜铃科马兜铃属中草药中,是马兜铃酸肾病(aristolochic acid nephropathy,AAN)的致病因素,此类肾病患者可伴发泌尿系统肿瘤,阐明马兜铃酸的致癌机制成为其毒性研究的一大焦点。马兜铃酸Ⅰ(AAⅠ)是马兜铃酸的主要毒性成分,其在体内经氧化还原后活化,与DNA共价结合形成加合物而诱发癌变。本文综述参与AAⅠ氧化还原的代谢酶及其代谢过程在AAⅠ致癌中的作用。Aristolochic acid（AA）,a major active component of Aristolochiaceae Aristolochia herbs,is the pathogenic factor of aristolochic acid nephropathy（AAN）. And AAN patients were usually complicated by urinary cancer.Therefore,the study on the carcinogenesis mechanisms of AA has become the focus in its toxicity research. Recently,researches have demonstrated that aristolochic acidⅠ（AAⅠ）was the main toxic component of AA,and was activated following the oxidation-reduction process. After activation, AA Ⅰ can induce carcinoma through forming AA Ⅰ-DNA adducts. This review summarizes the latest research of the enzymes participating in AAⅠ metabolism and their roles in the progress of AA carcinogenesis,which may provide references for follow-up research and its clinical application.

关 键 词：马兜铃酸 马兜铃酸Ⅰ 马兜铃酸Ⅰ-DNA加合物 代谢酶 致癌 

分 类 号：R285.5[医药卫生—中药学]