急性冠脉综合征患者外周血内皮祖细胞与冠状动脉病变程度的关系研究  

Relationship between Peripheral Blood Endothelial Progenitor Cells and Coronary Lesions in Patients with Acute Coronary Syndrome

作　　者：王海滨[1] 胡小燕[1] 任国瑞[1] 孙元芬[1] 康维强[1] 

机构地区：[1]山东省青岛市市立医院老年内科青岛市老年医学研究所,266071

出　　处：《实用心脑肺血管病杂志》2014年第11期12-13,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：青岛市科技局-青岛市民生科技计划项目【11-2-3-2-(10)-nsh】

摘　　要：目的探讨急性冠脉综合征患者外周血内皮祖细胞(EPCs)与冠状动脉病变程度的关系。方法选择2011年7月—2012年11月我院收治的急性冠脉综合征患者90例,根据冠状动脉造影结果分为复杂病变组48例和简单病变组42例。比较两组患者外周血EPCs计数,并分析其与冠状动脉病变程度的相关性。结果复杂病变组患者外周血EPCs计数为(30.4±7.0)个,少于简单病变组的(51.7±11.1)个(P<0.05)。直线相关分析结果显示,外周血EPCs计数与冠状动脉病变程度呈负相关(r=-0.427,P<0.05)。结论冠状动脉病变程度较重的急性冠脉综合征患者外周血EPCs计数减少,外周血EPCs或可成为预测冠状动脉病变程度的标志物。Objective To investigate the relationship between peripheral blood endothelial progenitor cells （ EPCs） and coronary lesions in patients with acute coronary syndrome （ ACS） .Methods A total of 90 ACS patients in our hospital were enrolled from July 2011 to November 2012, and they were divided into A group （with simple coronary lesions, n=42） and B group （with complex coronary lesions, n=42） according to coronary angiography results.Peripheral blood EPCs counts between the two groups were compared , and its correlation with coronary lesions was analyzed .Results Peripheral blood EPCs counts of B group was （30.4 ±7.0）, was less than that of A group of （51.7 ±11.1） （P〈0.05） .Linear correlation analysis result showed that, peripheral blood EPCs counts was negatively correlated with the severity of coronary lesions （r=-0.427, P〈0.05 ） .Conclusion Peripheral blood EPCs counts is reduced in ACS patients , and it may be a biomarker for predicting the se-verity of coronary lesions .

关 键 词：急性冠脉综合征 内皮祖细胞 冠状动脉病变 

分 类 号：R542.2[医药卫生—心血管疾病]