四氢姜黄素固体分散体对KK-Ay小鼠的抗糖尿病作用研究  

Effect Tetrahydrocurcumin-Solid Dispersion on KK-Ay Mice

作　　者：华桦[1] 廖利[2] 杨安东[1] 赵军宁[1] 

机构地区：[1]四川省中医药科学院药理毒理研究所,国家中医药管理局中药质量生物评价重点研究室,四川省道地药材系统开发工程技术研究中心,成都610041 [2]成都中医药大学,成都610075

出　　处：《中国药学杂志》2014年第24期2177-2180,共4页Chinese Pharmaceutical Journal

基　　金：国家"重大新药创制"科技重大专项(2011ZX09401-3042-1);国家科技支撑计划项目(2012BAI29B10);四川省科技支撑计划项目(2013sz0115);四川省科技厅成果转化项目(13010103)

摘　　要：目的研究四氢姜黄素固体分散体对KK-Ay小鼠的影响。方法以C 57/6J小鼠作为对照组,KK-Ay小鼠随机分为模型对照组、四氢姜黄素固体分散体组(100、50、15 mg·kg-1)和罗格列酮组(2.67 mg·kg-1),连续灌胃35 d,检测小鼠体重、空腹血糖、口服糖耐量、血清胰岛素和血脂等指标。结果四氢姜黄素固体分散体100 mg·kg-1组小鼠体重在给药第21天开始降低,并在给药期间维持在较低水平;四氢姜黄素固体分散体各剂量组从给药第14天起出现空腹血糖降低,同时可降低餐后血糖和AUC值;四氢姜黄素固体分散体各剂量组可降低总胆固醇和低密度脂蛋白胆固醇水平;四氢姜黄素固体分散体各剂量组胰岛素敏感指数均有所升高;四氢姜黄素固体分散体各剂量组糖化血清蛋白值均有降低趋势,仅100 mg·kg-1组与模型对照组比较统计差异显著。结论四氢姜黄素固体分散体可有效降低KK-Ay小鼠的血糖水平,并对糖代谢、脂质代谢有改善作用,其作用机制可能与增加胰岛素的敏感性有关。提示四氢姜黄素固体分散体可以改善胰岛素抵抗,用于预防或/和治疗胰岛素抵抗综合征及相关疾病。OBJECTIVE To study the effects tetrahydrocurcumin-solid dispersion on KK-AY mice. METHODS C 57 /6 J mice were used as controls,KK-Ay mice were randomly divided into model group,tetrahydrocurcumin-solid dispersion groups（ 100,50,15 mg·kg^-1） and rosiglitazone group（ 2. 67 mg·kg^-1）,gavage for 35 d,mouse weight,fasting blood glucose,oral glucose tolerance,serum insulin and blood lipid indexes were detected. RESULTS The weight mice tetrahydrocurcumin-solid dispersion group（ 100 mg·kg^-1） on twenty-first days administration began to decrease,and maintained at a low level during the administration; tetrahydrocurcumin-solid dispersion in each dose group showed impaired fasting blood glucose lowering from the fourteenth day after the administration began,and maintained at a low level during the administration,tetrahydrocurcumin-solid dispersion in each dose group can decrease postprandial blood glucose and AUC value; tetrahydrocurcumin-solid dispersion in each dose group can decrease the value TC,LDL-C,increase the insulin sensitivity index,tetrahydrocurcumin-solid dispersion in each dose group glycosylated serum protein values were decreased,while only in the 100 mg·kg^-1 group was statistical significant differences compared with the model group.CONCLUSION Tetrahydrocurcumin-solid dispersion,which can effectively reduce the blood glucose levels KK-AY mice,and has good effect on glucose metabolism,lipid metabolism. The mechanism action may be related to the increase insulin sensitivity.

关 键 词：四氢姜黄素 固体分散体 KK-AY小鼠 胰岛素抵抗 

分 类 号：R965[医药卫生—药理学]