瑞芬太尼麻醉患者术后痛觉过敏的回顾性研究  

Retrospective Study of Patients with Postoperative Hyperalgesia after Remifentanil Anesthesia

作　　者：谢芳华[1] 宋少波[1] 隗洁琼 姚圣杰[1] 

机构地区：[1]浙江萧山医院麻醉科,杭州311201

出　　处：《药物流行病学杂志》2014年第12期716-717,733,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：观察瑞芬太尼麻醉患者术后痛觉过敏情况。方法：采用回顾性分析法,收集2007-2012年我院200例应用瑞芬太尼麻醉手术患者作为研究对象,设为观察组。选择同期使用芬太尼麻醉手术195例患者,设为对照组。观察两组患者VAS疼痛评分的差异,评价患者机械性痛阈值的情况。结果：术前两组患者VAS疼痛评分差异无统计学意义（P〉0.05）;麻醉苏醒后,观察组90 min内不同时间点VAS疼痛评分较术前明显增高（P〈0.01）,且低于对照组同期（P〈0.05）。术前两组患者机械性痛阈值差异无统计学意义（P〉0.05）,麻醉苏醒后,观察组90 min内不同时间点机械性痛阈值较术前降低（P〈0.01）,且低于对照组同期（P〈0.05）。结论：瑞芬太尼易致术后痛觉过敏,其麻醉术后具有较高的疼痛感,机械性疼痛阈值也较低。临床使用瑞芬太尼时应采取相应的止痛措施进行干预治疗。Objective：To survey the patients with hyperalgesia situation after remifentanil anesthesia in operation. Methods ：200 cases of patients who did remifentanil anesthesia surgery from January 2007 to December 2012 were selected as the research objects in our hospital, set as experimental group. 195 patients of fentanyl anesthesia surgery were selected as control group. The difference of VAS pain score and mechanical pain treshald of patients between two groups and evaluated patients with mechanical pain threshold were observed. Results：VAS pain score of patients during preoperative between two groups had no significant difference （ P 〉 0.05 ）. VAS pain score of experimental group within 90 min after anesthesia a- wake at different times increase apparently, differences were statistically significant（P 〈0.01 ）, and was lower than that of control group at the same period, differences were statistically significant（ P 〈 0.05 ）. Patients of two groups with preopera- tive mechanical pain threshold had no statistical difference （ P 〉 0.05 ） , after anesthesia awake, mechanical pain threshold of experimental group within 90 min in different time points compared with preoperative significantly reduced, differences were statistically significant （ P 〈 0.01 ）, and was higher than that of control group at the same period, differences were statistically significant （P 〈 0.05 ）. Conclusion： Remifentanil anesthesia with fentanyl after hyperalgesia had higher pain after anaesthesia and mechanical pain threshold was low. When used remifentanil, intervene therapy measures should be taken to relief pain.

关 键 词：瑞芬太尼 芬太尼 麻醉 痛觉过敏 

分 类 号：R971.2[医药卫生—药品]