低剂量铂类化疗同步放射治疗治疗宫颈癌的临床疗效  

The clinical effect analysis of low dose platinum-based chemotherapy combined with concurrent radiotherapy for cervical cancer

作　　者：徐志渊[1] 林连兴[1] 颜明明[1] 

机构地区：[1]中山大学附属汕头医院放疗科,汕头515031

出　　处：《中国肿瘤临床与康复》2014年第12期1439-1442,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的评价低剂量铂类化疗同步放射治疗治疗宫颈癌的临床效果和不良反应。方法选取2008年9月至2011年5月治疗的82例宫颈癌患者,化疗采用奈达铂或顺铂20mg/m^2,每周一次,同期联合常规分割放射治疗及后装治疗,放射治疗总剂量为8000-8500c Gy。结果近期有效率达100%,1、2、3年生存率分别为90.2%、78.3%和76.3%。晚期放射损伤主要表现为放射性直肠炎及放射性膀胱炎,经积极治疗后均治愈或好转。结论低剂量铂类化疗联合同期放疗治疗宫颈癌,疗效好,不良反应轻。Objective To evaluate the therapeutic effects of low dose platinum-based chemotherapy combined with concurrent radiotherapy for cervical cancer. Methods From September 2008 to May 2011, 82 patients with cervical cancer were treated by radiotherapy （ conventional external radiation and after-loading brachytherapy, to a total dose of 8000-8500cGy） and p latinum-based chemotherapy （cisplatin or neda- platin 20mg/m^2, one time per week） ant the same period. Results The short-term effective rate was 100%. The 1,2, 3-year survival rate was 90. 2% , 78.3% and 76. 3% , respectively. The main late radiation injuries were radiation proctitis and radiocystitis. The complications of chemotherapy and radiotherapy were cured or recovered. Conclusions Low dose platinum-based chemotherapy combined with concurrent radiotherapy for cervical carcinoma is effective. The adverse reactions of chemoradiotherapy are slight.

关 键 词：宫颈肿瘤 放化疗 同步 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]