解脲支原体脂质相关膜蛋白与Toll样受体的相关性研究  

The Relevant Research between Lipid-associated Membrane Proteins of Ureaplasma Urealyticum and Toll-like Receptors

作　　者：王圆圆[1] 张洪文[1] 

机构地区：[1]中南大学湘雅二医院妇产科,长沙410011

出　　处：《国际妇产科学杂志》2014年第6期639-642,649,共5页Journal of International Obstetrics and Gynecology

摘　　要：解脲支原体(UU)是人泌尿生殖道中最常见的一种共生病原微生物,属于柔膜体纲支原体科,1954年Shperd从非淋菌性尿道炎患者尿道中分离出来,能分解尿素,有其特异的生化结构及功能。多数研究表明,UU浓度大于106拷贝/m L时有单独致病意义,与临床多种疾病发生发展有关。近年又证实,UU与人乳头瘤病毒(HPV)及人类免疫缺陷病毒(HIV)感染有关,且与HIV的传播有一定关系。UU在人群中的致病性一直是研究的重点,但是其发病机制尚未阐明。因此,某些与UU相关的疾病仍缺乏有效的防治。近年来,Toll样受体(TLRs)在启动宿主固有免疫和适应性免疫的作用成为研究热点,尤其是在感染性疾病中,UU及其脂质相关膜蛋白(LAMPs)可通过TLRs激活胞内信号转导通路诱导宿主细胞凋亡,这可能与多种疾病的发生有关。探索这一机制,阐述其发病进程有望为临床相关疾病的诊断和治疗提供新的方法。Ureaplasma urealyticum （UU） is the most common pathogenic microorganisms isolated from human urogenital tract, belonging to family mycoplasmataceae molicutes class. It is isolated from the patiens′urinary tract with non-gonococcal urethritis （NGU） by Shperd in 1954,UU can break down the urea and has its specific biochemical structure and function. Most studies showed that when UU concentration was more than 106 copy/mL in the urogenital tract,sole infection of UU can result in cinical diseases,and they contribute to the genesis and development of many clinical diseases. Recent studies confirmed that UU is associated with human papillomavirus （HPV） and human immunodeficiency virus （HIV） infection,and there is a certain relationship with the spread of HIV. Many researches has always been focused on the pathogenicity of UU ,but its pathogenesis has not been elucidated. So some with UU related diseases still lack of effective control. In recent years ,the role of toll-like receptors （TLRs） in activating the host innate and adaptive immune response become the hot of research ,especially infectious diseases. The lipid-assosiated membrane proteins （LAMPs） of ureaplasma urealyticum can activate intracellular signal transduction pathways by TLRs,induced host cell apoptosis,which may be associated with a variety of diseases. To explore the mechanism and illuminate the process are expected to provide new method for the diagnosis and treatment of clinical related diseases.

关 键 词：解脲支原体 膜蛋白质类 TOLL样受体 细胞凋亡 信号转导 

分 类 号：R711[医药卫生—妇产科学]