基于声电效应的生物电流源定位  

Localization of Bioelectric Current Source Based on Acousto-electric Effect

作　　者：张宁[1] 张鞠成 徐文龙[3] 王志康[2] 徐冰俏[3] 卢向红[1] 

机构地区：[1]丽水市人民医院,丽水323000 [2]浙江大学医学院附属二院临床医学工程部,杭州310009 [3]中国计量学院信息工程学院,杭州310018

出　　处：《高电压技术》2014年第12期3768-3772,共5页High Voltage Engineering

基　　金：国家质检总局公益性项目(201210079);浙江省科技厅项目(2011C33027;2014C37074);丽水市科技项目(20120302)~~

摘　　要：生物电流源的实时准确定位对于房颤等电生理疾病的诊断具有重要意义。为了进行生物电流源的2维定位,基于声电效应和互易定理,采用有限元法仿真分析了2维导联场,再通过MATLAB对导联场数据进行处理,其中仿真模型选取质量分数为0.9%的Na Cl溶液作为均匀导电介质。仿真结果表明,在均匀介质条件下,仅用1对探测电极即可实现生物电流源的精确定位,电流源和电流汇的仿真位置与实际位置之间的误差均≤0.04 mm。利用声电效应有望实现生物电流源的高精度实时定位,为房颤定位的临床实用化奠定了基础。Localization of bioelectric current source precisely in real time is of significance for diagnosing electrophysiology diseases like atrial fibrillation. To develop the 2-dimensional localization of bioelectric current source, we used the finite element method to simulate 2-dimensional lead fields based on the acousto-electric effect and reciprocal theory. Then we processed the corresponding data using MATLAB with a model that used Na Cl solution with the mass fraction of 0.9% as the homogeneous conducting medium. The simulation results showed that the excitation source was located accurately using only one pair of recording electrodes： the localization errors between the real and simulated positions of current sources and current sinks are all within 0.04 mm. It is concluded that, by the acousto-electric effect, we can realize the real-time high-precision localization of bioelectric current source, which lays the foundation for clinical applications of atrial fibrillation localization.

关 键 词：房颤 声电效应 生物电流源 电流密度成像 有限元法 2维定位 

分 类 号：O441[理学—电磁学]