5-芳胺基异噁唑的合成及表征  

Synthesis and Characterization of 5-Arylamino Isoxazole Derivatives

作　　者：茹婷婷[1] 石莹岩[1] 初学峰[1] 郑文琦[1] 

机构地区：[1]吉林建筑大学基础科学部,吉林长春130118

出　　处：《内蒙古师范大学学报（自然科学汉文版）》2014年第6期748-750,754,共4页Journal of Inner Mongolia Normal University(Natural Science Edition)

基　　金：吉林省自然科学基金资助项目(2011115187);吉林省科技发展计划项目(20140520080JH)

摘　　要：以ɑ-乙酰基环丙基乙酰芳胺、盐酸羟胺为原料,通过亲核取代反应合成了1-环丙基-N-苯基酰胺肟,在脱水剂PPh3/CBr4作用下,使用"一锅法"合成了具有专一结构的2-甲基-1-溴乙基-5-芳胺基异噁唑,并对该产物进行了1 H NMR和13 C NMR表征.1—cyclopropyl—N—phenyl amide oxime was synthesized from a—acetyl cyclopropyl acetanilide and hydroxylamine hydrochloride by nucleophilic substitution.2—methyl—1—ethyl—5—arylamino isoxazole was obtained from 1—cyclopropyl—N—phenyl amide oxime by one pot method under the dehydrating agent.The structures of the products were characterized by 1 H NMR and 13 C NMR.

关 键 词：5-芳胺基异噁唑 脱水剂 环合反应 

分 类 号：O626[理学—有机化学]